Background Administration of oral sucrose with and without non‐nutritive sucking is the most
frequently studied non‐pharmacological intervention for procedural pain relief in neonates …

Objective: To examine the effectiveness of any tocolytic compared with a placebo or no
tocolytic for preterm labor. Data Sources: We checked MEDLINE (1966–1998) and the …

Background Indomethacin is used as standard therapy to close a patent ductus arteriosus
(PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo …

Background Methylxanthines reduce the frequency of apnea of prematurity and the need for
mechanical ventilation during the first seven days of therapy. It is uncertain whether …

Objective: We sought to determine the associations between intrauterine growth restriction
and neonatal morbidity and mortality, as well as the impact of prenatal glucocorticoid …

Background Methylxanthine therapy is commonly used for apnea of prematurity but in the
absence of adequate data on its efficacy and safety. It is uncertain whether methylxanthines …

Background The prophylactic administration of indomethacin reduces the frequency of
patent ductus arteriosus and severe intraventricular hemorrhage in very-low-birth-weight …

Background As the interval between rupture of the fetal membranes at term and delivery
increases, so may the risk of fetal and maternal infection. It is not known whether inducing …

Background. Previous reports of variations in outcomes among neonatal intensive care units
(NICUs) examined only specific subpopulations of interest (eg, very low birth weight [VLBW] …

Objective To review outcomes in randomised controlled trials comparing hydralazine
against other antihypertensives for severe hypertension in pregnancy. Study design Meta …