User profiles for "author:A Vardon"
Ashley VardonDrug development fellow Verified email at ucl.ac.uk Cited by 270 |
Molecular basis and current strategies of therapeutic arginine depletion for cancer
Renewed interest in the use of therapeutic enzymes combined with an improved knowledge
of cancer cell metabolism, has led to the translation of several arginine depletion strategies …
of cancer cell metabolism, has led to the translation of several arginine depletion strategies …
The arginine metabolome in acute lymphoblastic leukemia can be targeted by the pegylated‐recombinant arginase I BCT‐100
C De Santo, S Booth, A Vardon… - … journal of cancer, 2018 - Wiley Online Library
Arginine is a semi‐essential amino acid that plays a key role in cell survival and proliferation
in normal and malignant cells. BCT‐100, a pegylated (PEG) recombinant human arginase …
in normal and malignant cells. BCT‐100, a pegylated (PEG) recombinant human arginase …
[HTML][HTML] Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with …
Background Radiotherapy is a valuable treatment in the management algorithm of pituitary
adenomas and craniopharyngiomas. However, the risk of second brain tumour following …
adenomas and craniopharyngiomas. However, the risk of second brain tumour following …
Macrophage-derived IL1β and TNFα regulate arginine metabolism in neuroblastoma
Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk
disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma …
disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma …
Efficient [18F]AlF Radiolabeling of ZHER3:8698 Affibody Molecule for Imaging of HER3 Positive Tumors
C Da Pieve, L Allott, CD Martins, A Vardon… - Bioconjugate …, 2016 - ACS Publications
The human epidermal growth factor receptor 3 (HER3) is overexpressed in several cancers,
being linked to a more resistant phenotype and hence leading to poor patient prognosis …
being linked to a more resistant phenotype and hence leading to poor patient prognosis …
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
…, L Gneo, U Scarpa, C Smith, A Vardon… - Blood …, 2023 - ashpublications.org
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and
viability. Similar mechanisms are applied by immune cells, resulting in the competition …
viability. Similar mechanisms are applied by immune cells, resulting in the competition …
Hierarchical Porous WO3@SiO2 Self-Standing Monolithic Catalysts and Their Efficient Cycling “Cosolvent-Free” Friedel–Crafts Alkylation/Acylation Catalytic …
A Vardon, E Layan, F Louërat, F Nallet… - Chemistry of …, 2023 - ACS Publications
Taking advantage of tungsten oxide inherent Brønsted–Lewis acidity, the first series of WO3–
SiO2 (HIPE) monolithic (MUB-104 (x) series) catalysts bearing multiscale porosity have …
SiO2 (HIPE) monolithic (MUB-104 (x) series) catalysts bearing multiscale porosity have …
Binary CoOx–SiO2 Porous Nanostructures for Catalytic CO Oxidation
I Ly, A Vardon, N Chanut, F Nallet… - ACS Applied Nano …, 2022 - ACS Publications
Via integrative chemistry, the first CoOx–SiO2 (HIPE) self-standing monoliths of cobalt nano-
oxides embedded within silica macro–mesocellular hosts have been prepared. These …
oxides embedded within silica macro–mesocellular hosts have been prepared. These …
[HTML][HTML] Arginine auxotrophic gene signature in paediatric sarcomas and brain tumours provides a viable target for arginine depletion therapies
A Vardon, M Dandapani, D Cheng, P Cheng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Paediatric sarcomas and brain tumours, remain cancers of significant unmet need, with a
poor prognosis for patients with high risk disease or those who relapse, and significant …
poor prognosis for patients with high risk disease or those who relapse, and significant …
Designing CuO–SiO2 and Cu0–SiO2 Monolithic Ceramics Bearing Hierarchical Porosity Toward Robust and Cycling CO Oxidation Properties
A Vardon, H Labarrère, F Nallet, N Chanut… - Chemistry of …, 2022 - ACS Publications
In the general context of environmental air remediation, copper-oxide-based self-standing
porous catalysts (MUB-103 (x)) and their reduced homologues (Red MUB-103 (x)) have …
porous catalysts (MUB-103 (x)) and their reduced homologues (Red MUB-103 (x)) have …