Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …

X‐box binding protein‐1 (XBP‐1) is a transcription factor essential for plasma cell
differentiation. XBP‐1 transcripts are found at high levels in plasma cells from rheumatoid …

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms
are poorly understood. Using cell culture and mouse models, we show that obesity causes …

Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the
intestinal microbiota. The transcription factor XBP1, a key component of the endoplasmic …

Glioblastoma is the most common primary malignant brain tumor in adults and is associated
with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a …

The mammalian unfolded protein response (UPR) protects the cell against the stress of
misfolded proteins in the endoplasmic reticulum (ER). We have investigated here the …

The differentiation of B cells into immunoglobulin-secreting plasma cells is controlled by two
transcription factors, Blimp-1 and XBP1. By gene expression profiling, we defined a set of …

Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical
enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a …

Evolutionary studies necessary to dissect diverse biological processes have been limited by
the lack of reverse genetic approaches in most organisms with sequenced genomes. We …