Abstract
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Acetaminophen / metabolism
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Adult
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Analgesics, Opioid / pharmacology*
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Depression, Chemical
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Gastrointestinal Motility / drug effects*
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Heroin / pharmacology
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Humans
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Intestinal Absorption / drug effects*
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Male
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Meperidine / pharmacology
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Pharmaceutical Preparations / metabolism*
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Time Factors
Substances
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Analgesics, Opioid
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Pharmaceutical Preparations
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Acetaminophen
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Heroin
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Meperidine