Abstract
We compared the immunogenicity of 7-valent pneumococcal-conjugate vaccine plus 23-valent pneumococcal vaccine to immunization with 23-valent vaccine only in individuals > or = 2 years of age with sickle cell disease. IgG pneumococcal antibody concentrations were higher in the combined schedule group with no increase in side effects observed after immunization with 23-valent vaccine.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adolescent
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Adult
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Anemia, Sickle Cell / immunology*
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Antibodies, Bacterial / biosynthesis*
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Bacterial Vaccines / administration & dosage
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Bacterial Vaccines / immunology*
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Child
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Child, Preschool
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Drug Administration Schedule
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Female
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Humans
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Male
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Streptococcus pneumoniae / immunology*
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / immunology*
Substances
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Antibodies, Bacterial
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Bacterial Vaccines
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Vaccines, Conjugate