Abstract
Eccrine glands are uniquely susceptible to a variety of pathologic processes. Alteration in the rate of sweat secretion manifests as hypohidrosis and hyperhidrosis. Obstruction of the eccrine duct leads to miliaria. The excretion of drugs into eccrine sweat may be a contributory factor in neutrophilic eccrine hidradenitis (NEH), syringosquamous metaplasia (SSM), coma bulla, and erythema multiforme (EM). Alterations in the electrolyte composition of eccrine sweat can be observed in several systemic diseases, most notably cystic fibrosis. This article summarizes current knowledge of eccrine gland pathophysiology.
MeSH terms
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Adult
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Blister / chemically induced
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Child
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Coma / chemically induced
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Cystic Fibrosis / metabolism
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Disease Susceptibility
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Drug-Related Side Effects and Adverse Reactions
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Eccrine Glands / metabolism
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Eccrine Glands / pathology
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Eccrine Glands / physiopathology*
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Electrolytes / analysis
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Erythema Multiforme / chemically induced
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Hidradenitis / chemically induced
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Humans
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Hyperhidrosis / etiology
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Hyperhidrosis / physiopathology
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Hypohidrosis / etiology
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Hypohidrosis / physiopathology
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Metaplasia
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Miliaria / etiology
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Miliaria / physiopathology
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Sweat / chemistry
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Sweat / metabolism
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Sweat Gland Diseases / chemically induced
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Sweat Gland Diseases / etiology
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Sweat Gland Diseases / physiopathology