Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity

T Rivera-Penera; R Gugig; J Davis; S McDiarmid; J Vargas; P Rosenthal; W Berquist; M B Heyman; M E Ament

doi:10.1016/s0022-3476(97)70359-7

Outcome of acetaminophen overdose in pediatric patients and factors contributing to hepatotoxicity

J Pediatr. 1997 Feb;130(2):300-4. doi: 10.1016/s0022-3476(97)70359-7.

Authors

T Rivera-Penera¹, R Gugig, J Davis, S McDiarmid, J Vargas, P Rosenthal, W Berquist, M B Heyman, M E Ament

Affiliation

¹ University of California, Medical Center, Los Angeles 90095, USA.

PMID: 9042136
DOI: 10.1016/s0022-3476(97)70359-7

Abstract

Seventy-three medical records of pediatric patients admitted for acetaminophen overdose were reviewed. Twenty-eight patients (39%) had severe liver toxic effects, and six of them underwent liver transplantation. Multiple miscalculated overdoses given by parents, with delay in therapy, are risk factors and the major cause of overdose in children 10 years of age or younger.

MeSH terms

Acetaminophen / administration & dosage
Acetaminophen / adverse effects*
Adolescent
Analgesics, Non-Narcotic / administration & dosage
Analgesics, Non-Narcotic / adverse effects*
California / epidemiology
Chemical and Drug Induced Liver Injury / epidemiology
Chemical and Drug Induced Liver Injury / etiology*
Chemical and Drug Induced Liver Injury / therapy
Child
Child, Preschool
Drug Overdose / epidemiology
Drug Overdose / etiology
Drug Overdose / therapy
Female
Humans
Infant
Liver Transplantation
Male
Medication Errors / statistics & numerical data
Retrospective Studies
Risk Factors
Treatment Outcome

Substances

Analgesics, Non-Narcotic
Acetaminophen