Abstract
A macrophage activation syndrome, possibly related to methotrexate toxicity, developed in a boy with systemic juvenile rheumatoid arthritis. Corticosteroid administration was ineffective, whereas a prompt response to cyclosporine was observed. Two months later, Pneumocystis carinii pneumonia developed.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / therapeutic use*
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Arthritis, Juvenile / drug therapy*
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Bone Marrow / ultrastructure
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Child
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Cyclosporine / administration & dosage
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Cyclosporine / therapeutic use*
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Humans
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Macrophage Activation / drug effects*
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Male
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Methotrexate / therapeutic use*
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Phagocytes / ultrastructure
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Pneumonia, Pneumocystis / drug therapy
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Sulfamethoxazole / administration & dosage
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Sulfamethoxazole / therapeutic use
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Trimethoprim / administration & dosage
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Trimethoprim / therapeutic use
Substances
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Anti-Infective Agents
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Antirheumatic Agents
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Cyclosporine
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Trimethoprim
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Sulfamethoxazole
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Methotrexate