Abstract
The safety and immunogenicity of two conjugate Haemophilus influenzae type B (Hib) vaccines administered either mixed with, or in separate limbs to, a whole-cell DTP vaccine, was compared in infants vaccinated at 2, 3 and 4 months of age. Antibody titres to purified polyribosylribitol phosphate, diphtheria, and to pertussis antigens between infants who received the Hib and DPT vaccines in separate limbs or in the same limbs were similar (P > 0.1) while antibody titres to tetanus toxoid were higher in the later group (P < 0.05). This study demonstrated that both Hib vaccines can be mixed with whole-cell DTP vaccine without reducing immunogenicity of either vaccine or increasing the incidence of adverse reactions.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / biosynthesis*
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Antibodies, Viral / blood
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Bacterial Capsules
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage*
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Diphtheria-Tetanus-Pertussis Vaccine / adverse effects
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Diphtheria-Tetanus-Pertussis Vaccine / immunology
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Haemophilus Vaccines / administration & dosage*
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Haemophilus Vaccines / adverse effects
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Haemophilus Vaccines / immunology
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Humans
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Immunization Schedule
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Infant
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Polysaccharides, Bacterial / administration & dosage*
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Polysaccharides, Bacterial / adverse effects
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Polysaccharides, Bacterial / immunology
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Tetanus Toxoid / administration & dosage*
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Tetanus Toxoid / adverse effects
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Tetanus Toxoid / immunology
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Vaccines, Combined / administration & dosage
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Vaccines, Combined / adverse effects
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Vaccines, Combined / immunology
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / adverse effects
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Viral
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Haemophilus influenzae type b polysaccharide vaccine
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Polysaccharides, Bacterial
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Tetanus Toxoid
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Vaccines, Combined
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Vaccines, Conjugate