Recurrent meningococcal septicaemia and properdin deficiency

N A Cunliffe; N Snowden; E M Dunbar; M R Haeney

doi:10.1016/s0163-4453(95)91550-8

Recurrent meningococcal septicaemia and properdin deficiency

J Infect. 1995 Jul;31(1):67-8. doi: 10.1016/s0163-4453(95)91550-8.

Authors

N A Cunliffe¹, N Snowden, E M Dunbar, M R Haeney

Affiliation

¹ Department of Infectious Diseases and Tropical Medicine, (Monsall Unit) North Manchester General Hospital, Crumpsall, U.K.

PMID: 8522838
DOI: 10.1016/s0163-4453(95)91550-8

Abstract

A 32-year-old male presented with two episodes of meningococcal septicaemia, each of which was caused by a different serogroup of Neisseria meningitidis. Examination of the alternative pathway of complement revealed the rare X-linked disorder properdin deficiency (PD). Meningococcal Infection in complement deficiency states is discussed and the unusual features of this case are highlighted.

Publication types

Case Reports

MeSH terms

Adult
Bacteremia / drug therapy
Bacteremia / microbiology*
Humans
Injections, Intravenous
Male
Meningococcal Infections / drug therapy
Meningococcal Infections / microbiology*
Neisseria meningitidis / isolation & purification*
Penicillin G / administration & dosage
Penicillin G / therapeutic use
Penicillins / administration & dosage
Penicillins / therapeutic use
Properdin / deficiency*

Substances

Penicillins
Properdin
Penicillin G