Abstract
We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that failed to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12-15 months before presentation.
MeSH terms
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Abdominal Pain / etiology
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Adolescent
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Child
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Child, Preschool
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Colon / pathology
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Colonic Diseases / etiology*
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Colonic Diseases / pathology
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Constriction, Pathologic / chemically induced
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Cystic Fibrosis / complications*
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Cystic Fibrosis / drug therapy
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Fibrosis / chemically induced
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Humans
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Intestinal Obstruction / etiology*
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Intestinal Obstruction / pathology
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Lipase / adverse effects
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Male
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Meconium
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Pancreatic Extracts / adverse effects*
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Pancreatin / adverse effects
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Pancrelipase
Substances
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Pancreatic Extracts
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Pancrelipase
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Pancreatin
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Lipase