Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes

Lancet. 1994 Jan 8;343(8889):85-6. doi: 10.1016/s0140-6736(94)90817-6.

Abstract

We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that failed to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12-15 months before presentation.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Pain / etiology
  • Adolescent
  • Child
  • Child, Preschool
  • Colon / pathology
  • Colonic Diseases / etiology*
  • Colonic Diseases / pathology
  • Constriction, Pathologic / chemically induced
  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / drug therapy
  • Fibrosis / chemically induced
  • Humans
  • Intestinal Obstruction / etiology*
  • Intestinal Obstruction / pathology
  • Lipase / adverse effects
  • Male
  • Meconium
  • Pancreatic Extracts / adverse effects*
  • Pancreatin / adverse effects
  • Pancrelipase

Substances

  • Pancreatic Extracts
  • Pancrelipase
  • Pancreatin
  • Lipase