Adverse cardiac manifestations following dextropropoxyphene overdose: can naloxone be helpful?

P Hantson; M Evenepoel; D Ziade; A Hassoun; P Mahieu

doi:10.1016/s0196-0644(95)70337-3

Adverse cardiac manifestations following dextropropoxyphene overdose: can naloxone be helpful?

Ann Emerg Med. 1995 Feb;25(2):263-6. doi: 10.1016/s0196-0644(95)70337-3.

Authors

P Hantson¹, M Evenepoel, D Ziade, A Hassoun, P Mahieu

Affiliation

¹ Department of Emergency and Intensive Medicine, Cliniques Universitaires St-Luc, Brussels, Belgium.

PMID: 7832361
DOI: 10.1016/s0196-0644(95)70337-3

Abstract

Dextropropoxyphene overdose may be complicated by serious cardiovascular manifestations, including conduction abnormalities and collapse. We report two patients in whom cardiac toxicity developed. Cardiovascular depression seemed to be improved after naloxone infusion in these two cases. Possible mechanisms are briefly discussed.

Publication types

Case Reports

MeSH terms

Adult
Arrhythmias, Cardiac / chemically induced
Arrhythmias, Cardiac / drug therapy*
Dextropropoxyphene / poisoning*
Drug Overdose / drug therapy
Female
Heart Block / chemically induced
Heart Block / drug therapy
Humans
Male
Middle Aged
Naloxone / therapeutic use*

Substances

Naloxone
Dextropropoxyphene