Abstract
The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype. The authors isolated and analysed the human TTF-1 gene, which shows a striking homology with the rat TTF-1 gene.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Cell Differentiation / genetics
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Cloning, Molecular
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Gene Expression Regulation
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Humans
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Iodide Peroxidase / genetics
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Molecular Sequence Data
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Nuclear Proteins / biosynthesis
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Nuclear Proteins / genetics*
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Receptors, Thyrotropin / genetics
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Sequence Homology, Nucleic Acid
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Thyroglobulin / genetics
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Thyroid Nuclear Factor 1
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Transcription Factors / biosynthesis
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Transcription Factors / genetics*
Substances
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NKX2-1 protein, human
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Nuclear Proteins
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Receptors, Thyrotropin
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Thyroid Nuclear Factor 1
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Transcription Factors
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Thyroglobulin
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Iodide Peroxidase