1 From the *Academic Unit of Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; †Department of Paediatric Infectious Diseases & Immunology, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; ‡Institute for Life Sciences, University of Southampton, Southampton, United Kingdom; §NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; ¶Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia; ‖University Children´s Hospital Basel, Paediatric Infectious Diseases and Pharmacology, University Basel, Basel, Switzerland; **Murdoch Children's Research Institute, Parkville, Victoria, Australia; ††Infectious Diseases Unit, Royal Children's Hospital Melbourne, Parkville, Victoria, Australia; ‡‡Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, United Kingdom; and §§University College London Institute of Child Health, London, United Kingdom.