Abstract
Fifty patients with seborrhoeic dermatitis were treated with 2% ketoconazole cream (n = 24) or with 1% hydrocortisone cream (n = 26) for 4 weeks in a double-blind comparative study. These twice daily applications resulted in 87.2% symptomatic improvement for hydrocortisone vs. 81.6% for ketoconazole. The number of P. ovale yeasts was significantly reduced after the application of ketoconazole compared with hydrocortisone. The incidence of side-effects was low in both groups.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Administration, Topical
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Anti-Inflammatory Agents / therapeutic use*
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Dermatitis, Seborrheic / drug therapy*
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Dermatitis, Seborrheic / microbiology
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Double-Blind Method
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Humans
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Hydrocortisone
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Ketoconazole / administration & dosage
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Ketoconazole / therapeutic use*
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Malassezia
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Randomized Controlled Trials as Topic
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Skin / microbiology
Substances
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Anti-Inflammatory Agents
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Ketoconazole
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Hydrocortisone