An adolescent girl presented with fever, headache, and mental status changes. Blood cultures 12 hours after admission were positive for Staphylococcus aureus. The initial evaluation did not reveal a source of the patient's sepsis. Forty-eight hours after admission a cardiac ejection click was detected. The chest radiograph showed ill-defined opacities compatible with pulmonary emboli in the right lung and a calcific density in the region of the right atrium. Echocardiogram confirmed the presence of a right atrial mass, which at surgery and upon histologic examination was a myxoma. Atrial myxomas are rare tumors in adolescents but should be considered in the differential diagnosis of suspected septic pulmonary emboli.