Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure

J Pediatr. 2011 Mar;158(3):505-7. doi: 10.1016/j.jpeds.2010.11.025. Epub 2010 Dec 28.

Abstract

Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / complications*
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Bacteremia / prevention & control
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Pneumococcal Infections / epidemiology*
  • Pneumococcal Infections / microbiology*
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines / immunology*
  • Prevalence
  • Serotyping
  • Streptococcus pneumoniae / classification*
  • Texas / epidemiology

Substances

  • Pneumococcal Vaccines