Abstract
Invasive pneumococcal disease (IPD) in children with sickle cell disease has decreased with prophylactic penicillin, pneumococcal polysaccharide vaccine, and pneumococcal protein-conjugate vaccine usage. We report 10 IPD cases since pneumococcal protein-conjugate vaccine licensure, including a recent surge of non-vaccine serotypes. IPD continues to be a serious risk in sickle cell disease.
Copyright © 2011 Mosby, Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Anemia, Sickle Cell / complications*
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Bacteremia / epidemiology
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Bacteremia / microbiology
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Bacteremia / prevention & control
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Child
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Child, Preschool
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Female
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Humans
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Infant
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Male
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Pneumococcal Infections / epidemiology*
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Pneumococcal Infections / microbiology*
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Pneumococcal Infections / prevention & control
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Pneumococcal Vaccines / immunology*
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Prevalence
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Serotyping
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Streptococcus pneumoniae / classification*
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Texas / epidemiology