Abstract
Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Age of Onset
-
Alleles
-
Chi-Square Distribution
-
Child
-
Diabetes Mellitus, Type 1 / genetics*
-
Diabetes Mellitus, Type 1 / metabolism
-
Fluorescent Antibody Technique
-
Genetic Predisposition to Disease
-
Genetic Testing
-
Humans
-
Islets of Langerhans / metabolism*
-
Neuropilin-1 / genetics*
-
Neuropilin-1 / metabolism
-
Polymorphism, Single Nucleotide / genetics
-
RNA, Messenger / genetics
-
RNA, Messenger / metabolism
Substances
-
RNA, Messenger
-
Neuropilin-1