Forty-nine nurses working in neonatal intensive care were surveyed by using measures of job stress, burnout, anxiety, and perceived social support. On the Maslach Burnout Inventory, they scored in a moderate range of burnout for emotional exhaustion and depersonalization and in a high range of burnout for sense of personal accomplishment. Stepwise regression analyses revealed that higher job stress scores, higher anxiety scores, perception of less supervisor (head nurse) support, and less experience were associated with higher burnout subscale scores.