Effects of botulinum toxin A therapy with electrical stimulation on spastic calf muscles in children with cerebral palsy

Am J Phys Med Rehabil. 2007 Nov;86(11):901-6. doi: 10.1097/PHM.0b013e3181520449.

Abstract

Objective: To assess the additive effect of adjuvant electrical stimulation on botulinum toxin A injection in children with spastic diplegic cerebral palsy.

Design: Eighteen children with dynamic foot equinus deformity were treated with botulinum toxin A injection into the calf muscles. Seven children were assigned to a treatment group who received botulinum toxin A and adjuvant electrical stimulation, and 11 children were assigned to a control group with botulinum toxin injection only. Before botulinum injection, and at 2 wks and 3 mos after injection, the Physician Rating Scale, passive ranges of ankle and knee motion, and the modified Ashworth scale were measured.

Results: A significant increase in passive range of ankle motion was observed at 2 wks after injection in the treatment group and at 3 mos after injection in both groups. Both groups showed significant improvements by the modified Ashworth scale at 2 wks after injection. Subscales of the Physician Rating Scale (equinus foot, crouched gait) and total Physician Rating Scale scores were significantly improved in the treatment group at 3 mos after injection, but this was not observed in the control group.

Conclusions: Adjuvant electrical stimulation for a short period after botulinum toxin A injection was found to benefit early improvement of range of motion and maintenance of gait improvement in children with spastic diplegia cerebral palsy showing dynamic equinus.

Publication types

  • Clinical Trial

MeSH terms

  • Botulinum Toxins, Type A / administration & dosage
  • Botulinum Toxins, Type A / therapeutic use*
  • Cerebral Palsy / rehabilitation*
  • Child
  • Child, Preschool
  • Electric Stimulation Therapy*
  • Female
  • Gait*
  • Humans
  • Infant
  • Injections, Intramuscular
  • Male
  • Muscle, Skeletal
  • Neuromuscular Agents / administration & dosage
  • Neuromuscular Agents / therapeutic use*
  • Range of Motion, Articular
  • Treatment Outcome

Substances

  • Neuromuscular Agents
  • Botulinum Toxins, Type A