Advances in CT technology are having profound impact on imaging children and have made CT angiography possible even in neonates. Even with the tiny anatomy of neonates, small volumes of contrast material, and small venous access catheters, successful CT angiography can be performed with attention to detail. Meticulous attention to patient preparation, the proper selection of technical factors, and optimal delivery of contrast material are crucial. Data post-processing and the creation of 3-D reconstructions are also essential in establishing a correct diagnosis. The applications of CT angiography are different in children than in adults and most applications in children involve assessment of congenital and postoperative vascular and cardiac diseases. The use of CT angiography offers the opportunity to eliminate the long periods of sedation associated with MR and reduce the radiation exposure associated with conventional angiography. Generally, the benefits of CT angiography in children outweigh the risk, namely that of radiation exposure. However, care must still be taken to minimize the radiation exposure.