Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta

Y Nishi; K Hamamoto; M Kajiyama; H Ono; M Kihara; K Jinno

doi:10.1016/s0022-3476(05)81809-8

Effect of long-term calcitonin therapy by injection and nasal spray on the incidence of fractures in osteogenesis imperfecta

J Pediatr. 1992 Sep;121(3):477-80. doi: 10.1016/s0022-3476(05)81809-8.

Authors

Y Nishi¹, K Hamamoto, M Kajiyama, H Ono, M Kihara, K Jinno

Affiliation

¹ Department of Pediatrics, Hiroshima Red Cross Hospital, Japan.

PMID: 1517930
DOI: 10.1016/s0022-3476(05)81809-8

Abstract

The effect of calcitonin therapy by injection or nasal spray on the incidence of bone fractures was studied in patients with osteogenesis imperfecta. In contrast to injection of calcitonin, intranasal administration of calcitonin twice a week for 2 weeks, followed by 2 weeks of no therapy, was simple and seemed beneficial for decreasing bone fractures in patients with osteogenesis imperfecta.

Publication types

Comparative Study

MeSH terms

Administration, Intranasal
Adolescent
Calcitonin / administration & dosage
Calcitonin / therapeutic use*
Child
Child, Preschool
Drug Evaluation
Female
Fractures, Bone / epidemiology
Fractures, Bone / etiology
Fractures, Bone / prevention & control*
Humans
Incidence
Infant
Injections
Male
Osteogenesis Imperfecta / complications
Osteogenesis Imperfecta / drug therapy*
Treatment Outcome

Substances

Calcitonin