Febrile infections can be fatal in travelers to tropical countries unless the patient seeks medical care in a timely manner and the physician takes the time and has the skill to make a rapid diagnosis and prescribe appropriate therapy. In addition to the usual febrile illnesses present in temperate climates, the patient may have an "exotic" infection, e.g., malaria, infectious hepatitis, enteric fever, or dengue fever. The potential causes of fever in travelers are extensive. This article provides practical clues to assist the physician in making the correct diagnosis--by using exposure information, symptoms and signs, and concomitant symptom complexes.