Abstract
We evaluated five children with prolonged primary hypothyroidism and noted a significant reduction in renal function (40%), which was reversible with hormonal replacement. This decline was higher than reported in adults and was of sufficient magnitude to warrant altering drug-dosing schedules. Furthermore, patients with moderately reduced renal function should be carefully evaluated for signs and symptoms of hypothyroidism.
MeSH terms
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Adolescent
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Age Determination by Skeleton
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Age Factors
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Child
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Contrast Media
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Female
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Glomerular Filtration Rate / physiology
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Humans
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Hypothyroidism / complications*
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Hypothyroidism / diagnosis*
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Hypothyroidism / drug therapy
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Iothalamic Acid
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Kidney Function Tests
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Male
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Prospective Studies
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Renal Insufficiency / diagnosis*
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Renal Insufficiency / etiology*
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Retrospective Studies
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Severity of Illness Index
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Thyrotropin / blood
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Thyrotropin / therapeutic use
Substances
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Contrast Media
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Iothalamic Acid
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Thyrotropin