Chest
Clinical InvestigationsASTHMARisk of Physician-Diagnosed Asthma in the First 6 Years of Life
Section snippets
Database
The Province of Manitoba has a relatively stable population of approximately 1.2 million people, and a universally accessible health-care system with fee for service as the method of physician payment. Payments depend on submission of claims that include the diagnosis, type of service, and the patient's identifier, date of birth, gender, and residential postal code. There is no record of ethnicity. Nonnominal records of medical services, including hospitalizations, are stored in the Manitoba
Results
There were 170,960 newborns followed up to their sixth birthday. Of these, 24,026 newborns (14.1%) were seen for asthma. The incidence was the highest in the first 2 years of life (2.6% and 2.9%, respectively) and declined to 2.0% in years 5 and 6. The cumulative incidence increased 2.3 times (95% CI, 2.2 to 2.5) from the cohort born in 1980 to that born in 1990.
Tables 1234show variables with significant HRs for the incidence of asthma. These HRs were derived from the model that included all
Discussion
There are several weaknesses associated with using administrative databases to study asthma. The first is the diagnosis of asthma. There is no objective test for asthma in children,15 and there may be labeling problems in relation to related diseases. We relied on the diagnosis submitted by the physician for payment of services. We defined the onset of asthma in three different ways and carried out analyses with each definition as the outcome. Because the same variables were identified as risk
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Cited by (64)
Maternal Distress During Pregnancy and Recurrence in Early Childhood Predicts Atopic Dermatitis and Asthma in Childhood
2020, ChestCitation Excerpt :Although the severity of AD and asthma was unable to be determined based on database limitations, the definitions used for asthma and AD have been previously validated in other studies.22,28,29 Potential confounding factors included sex, mode of delivery, low birth weight, preterm birth, newborn respiratory distress, maternal age, first pregnancy, maternal asthma and atopy, maternal smoking during pregnancy, urban location, low household income, and infant antibiotic use (as a proxy for respiratory infections) during infancy.30-32 Health database versions of these measures from our previous research were used.28
Regional Caesarean Delivery Practices, the Maternal-Infant Microbiome, and Risk for Asthma
2018, Journal of Obstetrics and Gynaecology CanadaPopulation-based study on association between birth weight and risk of asthma: A propensity score approach
2013, Annals of Allergy, Asthma and ImmunologyDeterminants of asthma after severe respiratory syncytial virus bronchiolitis
2012, Journal of Allergy and Clinical ImmunologyComparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
2011, Environmental Research
Support was provided by the Medical Research Council Canada.