Chest
Clinical Investigations in Critical CareIron Lung vs Mask Ventilation in the Treatment of Acute on Chronic Respiratory Failure in COPD Patients: A Multicenter Study
Section snippets
Study Design and Patient Selection
This matched retrospective cohort study was performed in patients with COPD who were in ARF and had been admitted to the RIICUs of Ospedale Careggi Firenze, Ospedale Forlanini Roma, Ospedale Maggiore Crema, and Ospedale Civico Palermo, over a period of 1 year, from January 1 to December 31, 1996. The patients admitted to Careggi Hospital and Forlanini Hospital who underwent NPV were designated as the NPV group. Those admitted to Crema Hospital and Palermo Hospital who underwent NIPPV were
Patients Included in the Study
Of a total of 393 patients with COPD who experienced ARF and were admitted to the RIICUs from January 1 to December 31, 1996, 53 pairs met the inclusion criteria (for either the NPV group or the NIPPV group) and were therefore evaluated. The patients reported herein included no cases of readmission to the hospital. The locations of the patients prior to admission to the RIICUs were the emergency department (NPV group, 40 patients; NIPPV group, 37 patients) and a medical ward (NPV group, 13
Discussion
The data of our study failed to demonstrate a difference in the mortality rate and treatment failure rate between patients with COPD and ARF treated with NPV and those treated with NIPPV.
This retrospective study is the first which formally compares two different noninvasive ventilatory techniques for the treatment of COPD patients experiencing ARF. A crucial factor for the validity of this study is the success in matching patients of the NPV group with those of the NIPPV group for important
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