CHEST
Clinical InvestigationsRelationship Between Bronchial Hyperresponsiveness and Development of Asthma in Wheezy Infants
Section snippets
Study Subjects
Fourteen infants with bronchiolitis (11 boys and 3 girls; agerange, 10 months to 2 years; mean age, 0.7 years) and 48 infants with wheezy bronchitis (25 boys and 23 girls; age range, 10 months to 6years; mean age, 2.3 years) participated in this study (Table 1). All subjects with bronchiolitis and 44 of the 48 subjects with wheezybronchitis were atopic. In this report, the clinical diagnosis of atopywas based on a positive family history of allergy or a positivereaction to common environmental
Results
During the methacholine inhalation challenge, the maximum decreasein tcPo2 was between 10 and 20 mm Hgin all children. All patients underwent the methacholine inhalationchallenge safely. There were no differences in baselinetcPo2 values among the bronchiolitis, wheezy bronchitis, asthma, and control groups (p > 0.1).
The mean value of Dmin-Po2 in infantswith bronchiolitis (8.1 ± 0.9 U) was significantly lower than thatin control subjects (21.0 ± 3.9 U) (p < 0.01) and wassignificantly higher than
Discussion
In this study, we showed that the meanDmin-Po2 in infants with bronchiolitis or wheezy bronchitis was lower than that in controlsubjects and was higher than that in asthmatic patients; 50% of children with bronchiolitis and 41% of children with wheezy bronchitiswho showed greater BHR subsequently developed asthma.
We previously evaluated BHR in infants with asthma by monitoringtcPo2. During an acute attack of asthma, tcPo2 correlates linearly tothe severity of the attack. Methacholine-induced
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Bronchial Hyperresponsiveness to Methacholine in Children Under 4 Years with Recurrent Bronchitis
2010, Archivos de BronconeumologiaEvaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life
2010, Journal of Allergy and Clinical ImmunologyCitation Excerpt :We had previously reported that infants and toddlers had heightened airway reactivity several months after a wheezy respiratory tract illness, which was still present 8 months after the acute illness.14 Similarly, Saga et al15 reported that heightened airway reactivity among wheezy infants was associated with having asthma as an older child. However, in the absence of a premorbid assessment of airway reactivity, it is difficult to interpret the relationships between airway reactivity and wheezing.
Physiology and respiratory functional exploration
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