Original ArticlesVery low birth weight newborns do not need repeat screening for congenital hypothyroidism☆
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Utility of Repeat Testing for Congenital Hypothyroidism in Infants with Very Low Birth Weight
2022, Journal of PediatricsCitation Excerpt :For the past 12 years, there have been several reports of false-negative initial NBS for thyroid function in infants with VLBW.9,10,21 TSH within the normal reference range on NBS may provide a false reassurance of euthyroidism in infants with VLBW, as shown by our data, consistent with several reports of preterm newborns who later required thyroid hormone therapy despite normal initial thyroid function results on the universal NBS in the first week of age.6,7,9,17,22,25,35-43 Although gestational age- or birth weight–specific normative data have only been reported for infants born preterm in a few studies,26 several investigators have proposed lowering the NBS TSH cutoff for infants born preterm to obviate the necessity for retesting at a later age during NICU course for infants with VLBW, as a way to identify infants with VLBW who might be at risk for congenital hypothyroidism.9,18,25,31
Same-sex twins have a high incidence of congenital hypothyroidism and a high probability to be missed at newborn screening
2020, Clinica Chimica ActaCitation Excerpt :In some countries and regions, secondary screening of TSH is routinely carried out at 2–4 weeks after birth to prevent missed diagnosis for various reasons such as premature delivery, low birth weight and multiple births [25,27–30]. However, based on the literature on the strategy of secondary screening, rescreening same-sex twins for primary CH is more justified [31]. According to our screening results, if the potential missed cases in twins are not taken into account, only the three pairs of twins that were diagnosed with CH had negative results (Twins 6, 7, and11).
Fetal and Postnatal Disorders of Thyroid Function
2020, Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical ManagementDisorders of the Thyroid in the Newborn and Infant
2020, Sperling Pediatric Endocrinology: Expert Consult - Online and PrintFetal and Postnatal Disorders of Thyroid Function
2019, Maternal-Fetal and Neonatal Endocrinology: Physiology, Pathophysiology, and Clinical Management
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Research in pediatric thyroid diseases at the Sainte-Justine Hospital is supported by its Research Center and by the Blouin-MacBain Foundation.