Original ArticlesAdiposity in childhood predicts obesity and insulin resistance in young adulthood☆,☆☆
Section snippets
Methods
This study was approved by the Committee for the Use of Human Subjects in Research at the University of Minnesota. Informed consent was obtained from participants and their parents when the subjects were age 13 and from the participants at the time of the insulin clamp studies.
The participants were recruited in the Sodium-Potassium Blood Pressure Trial in Children in 1985-198613 after blood pressure screening from 19,452 (93% of all enrolled) fifth to eighth-grade students in the Minneapolis
Results
The cohort consisted of 31 subjects (9 males and 22 females); two subjects were of mixed ethnic background, one was black, and 28 were white.
Age, blood pressure, and anthropometric measurements were not significantly different between this group of 31 subjects and the remaining 200 subjects of the initial cohort. Age, blood pressure, and body size measurements at baseline (age 13) and young adulthood (age 22) are listed in Table I.Empty Cell
Discussion
This study shows that BMI in childhood is strongly correlated with BMI in young adulthood and predicts insulin resistance. Although only 4 of the subjects had a BMI ≥27 kg/m2 at age 13, an additional 12 subjects had reached a BMI of 27 by age 22. Although more females (n = 8) than males (n = 4) became overweight by age 22, the total percentages of overweight males (5/9, 55%) and females (11/22, 50%) are similar. The explanation for a relatively large percentage of the cohort increasing their
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Supported by grants No. HL 34659, No. HL 04000, and No. M01 RR00400 from the National Institutes of Health.
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Reprint requests: Julia Steinberger, MD, Pediatric Cardiology, MMC 94, University of Minnesota, 420 Delaware St, SE, Minneapolis, MN 55455.