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Am J Perinatol 1992; 9(5/06): 409-410
DOI: 10.1055/s-2007-999276
ORIGINAL ARTICLE

© 1992 by Thieme Medical Publishers, Inc.

Neonatal Thrombosis with Anticardiolipin Antibody in Baby and Mother

Salim Contractor, Mark Hiatt, Martin Kosmin, Hugh C. Kim
  • Department of Medicine and Pediatrics, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

The anticardiolipin antibody is associated with increased risk of thrombosis, which is manifested with various clinical presentations, including vascular thrombosis, recurrent fetal wastage, and neurologic defects. We report a case of neonatal thrombosis occurring in the renal vein and inferior vena cava associated with moderate positive anticardiolipin antibody titer in the baby while the maternal serum showed even stronger anticardiolipin antibody of immunoglobulin G class. Subsequent follow-up over the 4 months postpartum period showed a disappearance of the antibody in the baby, whereas the mother's antibody persisted. This case illustrates the fact that the maternal anticardiolipin antibody can be transferred to the fetus and may be a risk factor for thrombosis in the neonates. Anticardiolipin antibody syndrome should be considered in the differential diagnosis of neonatal thrombosis.

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