Elsevier

Respiratory Medicine

Volume 94, Issue 7, July 2000, Pages 709-714
Respiratory Medicine

Regular Article
Inhaled nebulized adrenaline improves lung function in infants with acute bronchiolitis

https://doi.org/10.1053/rmed.2000.0807Get rights and content
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Abstract

β2-agonists have questionable symptomatic effect in infants with acute bronchiolitis, whereas inhaled, nebulized racemic adrenaline, commonly used in Norway, appears (clinically) to be effective. Limited lung function observations during acute bronchiolitis exists, and less for assessing possible effects inhaled adrenaline.

In this preliminary study, tidal flow-volume loops were measured in 16 infants with acute bronchiolitis and seven healthy controls (mean age 7·9 and 4·4 months, respectively), with repeated measurements 15 min after inhaled nebulized racemic adrenaline (4 mg diluted in 2 ml saline) in nine bronchiolitis patients.

The ratio of time to reach peak tidal expiratory flow to total expiratory time (tPTEF/tE) was significantly reduced in children with acute bronchiolitis (mean, 95% CI) (0·08, 0·05–0·10) compared to controls (0·31, 0·18–0·43), with significant improvement after inhaled racemic adrenaline 0·19 (0·13–0·25), parallel with significant clinical improvement.

Lung function (tPTEF/tE) was reduced in infants with acute bronchiolitis and improved significantly after inhaled racemic adrenaline. Inhaled racemic adrenaline is potentially an important alternative for treating infants with acute bronchiolitis.

Keywords

tidal flow volume loops
lung function
bronchiolitis
racemic adrenaline
nebulized.

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Correspondence should be addressed to: Karin C. Lødrup Carlsen, Section of Allergology and Pulmonology, Department of Paediatrics, Woman Child Clinic, Ullevål Hospital, N-0407 Oslo, Norway. Fax: +47 22 11 86 6; E-mail: [email protected]