Clinical Advances in Liver, Pancreas, and Biliary TractHeritability of Nonalcoholic Fatty Liver Disease
Section snippets
Probands
Because most children with NAFLD are overweight or obese, all probands were required to be overweight or obese.15 Probands were further selected on the basis of the presence or absence of NAFLD. The diagnosis of NAFLD was based on the following: (1) liver biopsy with at least 5% or greater of hepatocytes containing macrovesicular fat,16 and (2) exclusion of other causes of chronic liver disease including hepatitis B (hepatitis B surface antigen), hepatitis C (hepatitis C antibody), α-1
Description of Probands
Details for the probands are shown in Table 1. There were 33 children with biopsy-proven NAFLD and 11 children without NAFLD. Age and BMI did not differ between the groups. The distribution of overweight and obesity also was the same for both groups: 18% overweight and 82% obese. The racial and ethnic distribution for children with NAFLD was as follows: 23 of 33 (70%) were white Hispanic, 7 of 33 (21%) were white non-Hispanic, and 3 of 33 (9%) were Native American Indian Hispanic. For children
Discussion
We performed a familial aggregation study of fatty liver in overweight children with and without NAFLD. In family members, the presence or absence of fatty liver was documented using MRI. Clinical history and laboratory testing were applied to exclude participants with alternate explanations for fatty liver other than NAFLD. The main finding was that liver fat fraction and the condition of fatty liver are heritable traits. The estimate for the heritability of the fatty liver as a dichotomous
Acknowledgments
The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
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Conflict of interest The authors disclose no conflicts.
Funding This work was funded in part by grants from the National Institutes of Health including R21 DK71486 from the National Institute of Diabetes and Digestive and Kidney Diseases, P60 MD00220 for the San Diego EXPORT Center from the National Center of Minority Health and Health Disparities, and M01 RR000827 from the National Center for Research Resources for the General Clinical Research Center at University of California, San Diego, and grant DK080506 from the UCSD Digestive Diseases Research Development Center, San Diego. Dr Salem and Dr Schork are supported in part by Scripps Genomic Medicine and The Scripps Translational Sciences Institute.