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Randomized Trial of Normal Saline versus 5% Albumin for the Treatment of Neonatal Hypotension

Journal of Perinatology volume 23, pages 473–476 (2003)Cite this article

Abstract

OBJECTIVES: This study was designed to assess the comparative efficacy of normal saline (NS) and 5% albumin (ALB) for treatment of hypotension in the acutely ill newborn.

STUDY DESIGN: Newborn infants who were <24 hours old and were admitted to the Holden Neonatal Intensive Care Unit at the University of Michigan were randomized to receive one of the two solutions for volume expansion. Hypotension was defined as a sustained (≥30 minutes) mean arterial pressure (MAP) of <30 mmHg for infants weighing ≤2500 g, or a MAP of <40 mmHg for those weighing >2500 g. The short-term outcome measure was the resolution of hypotension defined as a MAP over the minimum limits set for birthweight sustained for ≥30 minutes.

RESULTS: In total 41 infants met criteria and were entered. Of these, 21 infants received ALB and 20 received NS. Successful treatment was seen in 17/21 (81%) of infants in the ALB group and 17/20 (85%) of infants in the NS group. There was no statistically significant difference in response to treatment (p=0.30). In addition, there was no statistically significant difference in the magnitude of change in MAP between the two (p=0.41).

CONCLUSIONS: NS was shown to be as effective as ALB for the correction of acute hypotension in the newborn infant. Given comparable efficacy of NS, along with its relatively low cost and availability, it should be considered the initial treatment of choice in this setting.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Michigan Health System, Ann Arbor, MI, USA

    Melisa J Oca MD, Martha Nelson MD & Steven M Donn MD

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  1. Melisa J Oca MD
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  2. Martha Nelson MD
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  3. Steven M Donn MD
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Oca, M., Nelson, M. & Donn, S. Randomized Trial of Normal Saline versus 5% Albumin for the Treatment of Neonatal Hypotension. J Perinatol 23, 473–476 (2003). https://doi.org/10.1038/sj.jp.7210971

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