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An evolving scientific basis for the prevention and treatment of pediatric obesity

International Journal of Obesity volume 38, pages 887–905 (2014)Cite this article

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Abstract

The 2013 Pennington Biomedical Research Center’s Scientific Symposium focused on the treatment and management of pediatric obesity and was designed to (i) review recent scientific advances in the prevention, clinical treatment and management of pediatric obesity, (ii) integrate the latest published and unpublished findings and (iii) explore how these advances can be integrated into clinical and public health approaches. The symposium provided an overview of important new advances in the field, which led to several recommendations for incorporating the scientific evidence into practice. The science presented covered a range of topics related to pediatric obesity, including the role of genetic differences, epigenetic events influenced by in utero development, pre-pregnancy maternal obesity status, maternal nutrition and maternal weight gain on developmental programming of adiposity in offspring. Finally, the relative merits of a range of various behavioral approaches targeted at pediatric obesity were covered, together with the specific roles of pharmacotherapy and bariatric surgery in pediatric populations. In summary, pediatric obesity is a very challenging problem that is unprecedented in evolutionary terms; one which has the capacity to negate many of the health benefits that have contributed to the increased longevity observed in the developed world.

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Acknowledgements

SB is supported in part by 1U18 DP00336l7-01 Systems Approach to Obesity Prevention in Underserved Children in Texas, Centers for Disease Control and Prevention and by NIH/NIDDK 5U01DK 061718 Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). CB is funded, in part, by the John W Barton, Sr. Endowed Chair in Genetics and Nutrition. PMC is funded by NICHD HD22965-19 and the Clinical Research Unit of the CTSCUL1TR000439 from NCATS at Case Western Reserve University. THI is supported in part by grant UM1DK072493 from the National Institute of Diabetes and Digestive and Kidney Diseases. PTK is partially supported by the Marie Edana Corcoran Endowed Chair in Pediatric Obesity and Diabetes. DS-M is partly supported by National Center for Research Resources and the Office of Science Education of the National Institutes of Health through grant number R25 RR011113. HR has received research funding from Weight Watchers, International. LMR is supported by funding from the National Institutes of Health (U01DK094418, R01099175, R00HD0607662). AES is supported, in part, by 1 U54 GM104940 from the National Institute of General Medical Sciences of the National Institutes of Health, which funds the Louisiana Clinical and Translational Science Center. MV is supported in part by Gravida: National Centre for Growth and Development and The Marsden Fund of the Royal Society of New Zealand. DW is supported in part, by the Scott Rudolph University Endowed Professor in Psychiatry, Medicine, Pediatrics and Psychology. Her other support includes NIH grantsK24MH070446-09; R01HD036904-01A1; T32HL007456-30; P30DK056341 NORC, and her research reported in this publication was supported by the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official view of the NIH. JAY is supported by the Intramural Research Program of NICHD, NIH and is a Commissioned Officer in the US Public Health Service, Department of Health and Human Services. The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the US Public Health Service, the National Institutes of Health or the US Department of Health and Human Services.

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Authors and Affiliations

  1. Pennington Biomedical Research Center, Baton Rouge, LA, USA

    P T Katzmarzyk, C Bouchard, D S Hsia, L M Redman & A E Staiano

  2. Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA

    S Barlow

  3. MetroHealth Medical Center/Case Western Reserve University, Cleveland, OH, USA

    P M Catalano

  4. Division of Pediatric Surgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    T H Inge

  5. University of North Carolina at Greensboro, Greensboro, NC, USA

    C Lovelady

  6. University of Tennessee, Knoxville, TN, USA

    H Raynor

  7. Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA

    D Spruijt-Metz

  8. Academic Child Health, School of Clinical Medicine, University Hospital, University of Nottingham, Nottingham, UK

    M E Symonds

  9. Liggins Institute, University of Auckland, Auckland, New Zealand

    M Vickers

  10. Department of Psychiatry, Washington University, St Louis, MO, USA

    D Wilfley

  11. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    J A Yanovski

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Competing interests

CB is a scientific advisor to Weight Watchers, Pathway Genomics and Nike SPARQ. THI receives research funding from Ethicon Endosurgery. DW serves as an advisor to Shire and United Health Group. JAY has received orlistat and matching placebo from Roche and betahistine and matching placebo and grant support from Obecure for prior studies. The remaining authors declare no conflict of interest.

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Katzmarzyk, P., Barlow, S., Bouchard, C. et al. An evolving scientific basis for the prevention and treatment of pediatric obesity. Int J Obes 38, 887–905 (2014). https://doi.org/10.1038/ijo.2014.49

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