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Genetics of Autism: Overview and New Directions

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Abstract

Genetic epidemiology is the study of inherited factors involved in the etiology of a disease or disorder and uses the methods of both medical genetics and clinical epidemiology. In general, genetic epidemiology tries to answer the following four questions: Is the disorder inherited; What phenotype is inherited; How is it inherited or what is the mode of transmission; and What is the nature of the genetic mutation, if any, that gives rise to the disorder? The hope is that by identifying the gene or genes involved in pathophysiology, a much better understanding of the steps from gene product to phenotype will be possible, leading to improvements in diagnosis, an opportunity for thoughtful family planning, and perhaps, most important, to the development of treatments based on an understanding of the biochemistry of the disorder. We review the current knowledge of the genetic epidemiology of autism and the other pervasive developmental disorders (PDDs) and highlight promising new directions. There seems to be widespread agreement that the PDDs are caused, at least in part, by genetic factors. There is also some agreement on the phenotypic boundaries associated with these same genetic factors. However, many points of uncertainty remain, and several methodologic issues need to be resolved before further progress in mapping susceptibility genes is possible. We do not specifically review molecular studies, medical conditions associated with autism, or the broader autism phenotype, as these topics are covered in other papers in this special issue.

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REFERENCES

  • Aitman, T. J., & Todd, J. A. (1995). Molecular genetics of diabetes mellitus. Baillieres Clinical Endocrinology & Metabolism, 9, 631–656.

    Google Scholar 

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., Rev.). Washington, DC: Author.

    Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.

    Google Scholar 

  • August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. British Journal of Psychiatry, 138, 416–442.

    Google Scholar 

  • Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.

    Google Scholar 

  • Bailey, A., Palferman, S., Heavey, L., & Le Couteur, A. (1998). Autism: The phenotype in relatives. Journal of Autism and Developmental Disorders, 28, 369–392.

    Google Scholar 

  • Baird, T. D., & August, G. J. (1985). Familial heterogeneity in infantile autism. Journal of Autism and Developmental Disorders, 15, 315–321.

    Google Scholar 

  • Bartak, L., Rutter, M., & Cox, A. (1975). A comparative study of infantile autism and specific developmental receptive language disorder. British Journal of Psychiatry, 126, 127–145.

    Google Scholar 

  • Bolton, P., & Holland, A. (1994). Chromosomal abnormalities. In M. Rutter, E. Taylor, & L. Hersov (Eds.), Child and adolescent psychiatry: modern approaches (3rd ed., pp. 152–171). Oxford, England: Blackwell.

    Google Scholar 

  • Bolton, P., MacDonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877–900.

    Google Scholar 

  • Bolton, P. F., Murphy, M., Macdonald, H., Whitlock, B., Pickles, A., & Rutter, M. (1997). Obstetric complications in autism: Consequences or causes of the condition? Journal of the American Academy of Child and Adolescent Psychiatry, 36, 272–281.

    Google Scholar 

  • Boutin, P., Maziade, M., Mérette, C., Mondor, M., Bedard, C., & Thivierge, J. (1997). Family history of cognitive disabilities in first-degree relatives of autistic and mentally retarded children. Journal of Autism and Developmental Disorders, 27, 165–176.

    Google Scholar 

  • Bryson, S. E., Smith, I. M., & Eastwood, D. (1988). Obstetrical suboptimality in autistic children. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 418–422.

    Google Scholar 

  • Chess, S. (1971). Autism in children with congenital rubella. Journal of Autism and Childhood Schizophrenia, 1, 33–47.

    Google Scholar 

  • Cook, E. H., Charak, D. A., Arida, J., Spohn, J. A., Roizen, N. J. M., & Leventhal, B. L. (1994). Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorders. Psychiatry Research, 52, 25–33.

    Google Scholar 

  • Cook, E. H., Courchesne, R., Lord, C., Cox, N. J., Yan, S., Lincoln, A., Haas, R., Courchesne, E., & Leventhal, B. L. (1997). Evidence of linkage between the serotonin transporter and autistic disorder. Molecular Psychiatry, 2, 247–250.

    Google Scholar 

  • Corder, E. H., & Woodbury, M. A. (1993). Genetic heterogeneity in Alzheimer's disease: A grade of membership analysis. Genetic Epidemiology, 10, 495–499.

    Google Scholar 

  • DeLong, R. G., & Dwyer, J. T. (1988). Correlation of family history with specific autistic subgroups: Asperger's Syndrome and bipolar affective disease. Journal of Autism and Developmental Disorders, 18, 593–600.

    Google Scholar 

  • Deykin, E. Y., & McMahon, B. (1979). Rubella: Viral exposure and autism. American Journal of Epidemiology, 109, 628–38.

    Google Scholar 

  • Deykin, E. Y., & McMahon, B. (1980). Pregnancy, delivery and neonatal complications among autistic children. American Journal of Diseases of Childhood, 134, 860–864.

    Google Scholar 

  • Faraone, S. V., & Tsuang, M. T. (1995). Methods in Psychiatric Genetics. In M.T. Tsuang, M. Tohen, & G. E. P. Zahner (Eds.), Textbook in Psychiatric Epidemiology, (pp. 81–134). New York: Wiley Liss.

    Google Scholar 

  • Ferguson, R. A., & Goldberg, D. M. (1997). Genetic markers of alcohol abuse. Clinical Chimica Acta, 257, 199–250.

    Google Scholar 

  • Fisman, S., Wolf, L., Ellison, D., Gillis, B., Freeman, T., & Szatmari, P. (1996). Risk and protective factors affecting the adjustment of siblings of children with chronic disabilities. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 1532–1541.

    Google Scholar 

  • Folstein, S. (1996). Twin and adoption studies in child and adolescent psychiatric disorders. Current opinion in Pediatrics, 8, 339–347.

    Google Scholar 

  • Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321.

    Google Scholar 

  • Fombonne, E. (1997). Epidemiological surveys of autism. To appear in F. Volkmar (Eds.), C.U.P. Monograph on Autism.

  • Fombonne, E., Bolton, P., Prior, J., Jordan, H., & Rutter, M. (1997). A family study of autism: Cognitive patterns and levels in parents and siblings. Journal of Child Psychology and Psychiatry, 38, 667–683.

    Google Scholar 

  • Fuller, J. L., & Thomson, M. (1960). Behavior genetics. New York: Wiley.

    Google Scholar 

  • Gillberg, C. (1991). Outcome in autism and autistic-like conditions. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 375–382.

    Google Scholar 

  • Gillberg, C., & Gillberg, I. C. (1983). Infantile autism: A total population study of reduced optimality in the pre-, peri-, and neonatal periods. Journal of Autism and Developmental Disorders, 13, 153–166.

    Google Scholar 

  • Gillberg, C., Gillberg, I. C., & Steffenberg, S. (1992). Siblings and parents of children with autism: A controlled population-based study. Developmental Medicine and Child Neurology, 34, 389–398.

    Google Scholar 

  • Gillberg, C., & Svendsen, P. (1983). Childhood psychosis and computer tomographic brain scan findings. Journal of Autism and Developmental Disorders, 13, 19–32.

    Google Scholar 

  • Gillberg, I. C., & Gillberg, C. (1989). Asperger syndrome—some epidemiological considerations: A research note. Journal of Child Psychology and Psychiatry, 30, 631–638.

    Google Scholar 

  • Gold, N. (1993). Depression and social adjustment in siblings of boys with autism. Journal of Autism and Developmental Disorders, 23, 147–163.

    Google Scholar 

  • Gonez-Isla, T., West, H. L., Rebek, G. W., Harr, S. D., Growden, J. H., Locascio, J. J., Perls, T. T., Lipsitz, L. Z., & Hyman, B. T. (1996). Clinical and pathological correlates of apolipoprotein E epsilong 4 in Alzheimer's disease. Annals of Neurology, 39, 62–70.

    Google Scholar 

  • Goodman, R. (1990). Technical note: Are perinatal complications causes or consequences of autism? Journal of Child Psychology and Psychiatry, 31, 809–812.

    Google Scholar 

  • Hallmayer, J., Hebert, J., Spiker, D., Lotspeich, L., McMahon, W. M., Petersen, P. B., Nicholas, P., Pingree, C., Lin, A. A., Cavalli-Sforza, L. L., Risch, N., & Ciranello, R. D. (1996). Autism and the X chromosome. Archives of General Psychiatry, 53, 985–989.

    Google Scholar 

  • Hallmayer, J., Spiker, D., Lotspeich, L., McMahon, W. M., Petersen, P. B., Nicholas, P., Carmen, P., & Ciranello, R. D. (1996). Male-to-male transmission in extended pedigrees with multiple cases of autism. American Journal of Medical Genetics, 67, 13–18.

    Google Scholar 

  • Hanson, D. R., & Gottesman, I. (1976). The genetics, if any, of infantile autism and childhood schizophrenia. Journal of Autism and Childhood Schizophrenia, 6, 209–234.

    Google Scholar 

  • Hughes, C., Leboyer, M., & Bouvard, M. (1997). Executive function in parents of children with autism. Psychological Medicine, 27, 209–220.

    Google Scholar 

  • Jones, M. B., & Szatmari, P. (1988). Stoppage rules and genetic studies of autism. Journal of Autism and Developmental Disorders, 18, 31–40.

    Google Scholar 

  • Jorde, L. B., Hasstedt, S. J., Ritvo, E. R., Mason-Brothers, A., Freeman, B. J., Pingree, C., McMahon, W. M., Petersen, B., Jenson, W. R., & Moll, A. (1991). Complex segregation analysis of autism. American Journal of Human Genetics, 49, 932–938.

    Google Scholar 

  • Khoury, M. J., Beatty, T. H., & Cohen, B. H. (1993). Fundamentals of genetic epidemiology. New York; Oxford University Press.

    Google Scholar 

  • Le Couteur, A., Bailey, A., Goode, S., Pickles, A., Robertson, S., Gottesman, I., & Rutter, M. (1996). A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801.

    Google Scholar 

  • Le Couteur, A., Rutter, M., Lord, C., Rios, P., Robertson, S., Holdgrafer, M., & McLennan, J. D. (1989). Autistic Diagnostic Interview—Revised. Journal of Autism and Developmental Disorders, 19, 363–389.

    Google Scholar 

  • Levy, S., Zoltak, B., & Saelens, T. (1988). A comparison of obstetrical records of autistic and nonautistic referrals for psychoeducational evaluations. Journal of Autism and Developmental Disorders, 18, 573–581.

    Google Scholar 

  • Lord, C., Mulloy, C., Wendelboe, M., & Schopler, E. (1991). Pre-, peri-, and neonatal factors in high-functioning females and males with autism. Journal of Autism and Developmental Disorders, 21, 197–209.

    Google Scholar 

  • MacKinnon, D. F., Jamison, K. R., & DePaulo, J. R. (1997). Genetics of manic depressive illness. Annual Review of Neuroscience, 20, 355–273.

    Google Scholar 

  • MacLean, J. E., Szatmari, P., Jones, M. B., Bryson, S. E., Mahoney, W. J., Bartolucci, G., & Tuff, L. (1998). Familial factors influence the severity of pervasive developmental disorders: Evidence for possible genetic heterogeneity. Manuscript submitted for publication.

  • Mattson, M. P. (1988). Neurotransmitters in the regulation of neuronal cytoarchitecture. Brain Research Reviews, 13, 179–212.

    Google Scholar 

  • Murphy, K. C., Cardno, A. G., & McGuffin, P. (1996). The molecular genetics of schizophrenia. Journal of Molecular Neuroscience, 7, 147–157.

    Google Scholar 

  • Narod, S. A., Ford, D., Devilee, P., Barkardottir, R. B., Lynch, H. T., Smith, S. A., Ponder, B. A. J., Weber, B. L., Garber, J. E., Birch, J. M., Cornelis, R. S., Kelsell, D. P., Spurr, N. K., Smyth, E., Haites, N., Sobol, H., Bignon, Y. J., Chang-Claude, J., Hamann, U., Lindblom, A., Borg, A., Piver, M. S., Gallion, H. H., Struewing, J. P., Whittemore, A., Tonin, P., Goldgar, D. E., Easton, D. F., & the Breast Cancer Linkage Consortium (1995). An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families. American Journal of Human Genetics, 56, 254–264.

    Google Scholar 

  • Nelson, K. B. (1991). Prenatal and perinatal factors in the etiology of autism. Pediatrics, 87, 761–766.

    Google Scholar 

  • Ott, J. (1985). Analysis of human genetic linkage. Baltimore: Johns Hopkins University Press.

    Google Scholar 

  • Ozonoff, S., Rogers, S. J., Farnham, S. M., & Pennington, B. F. (1993). Can standard measures identify subclinical markers of autism? Journal of Autism and Developmental Disorders, 23, 429–441.

    Google Scholar 

  • Pickles, A., Bolton, P., Macdonald, H., Bailey, A., Le Couteur, A., Sim, C.-H., & Rutter, M. (1995). Latent class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism. American Journal of Human Genetics, 57, 717–726.

    Google Scholar 

  • Piven, J., Chase, G. A., Landa, R., Wzorek, M., Gayle, J., Cloud, D., & Folstein, S. (1991). Psychiatric disorders in the parents of autistic individuals. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 471–478.

    Google Scholar 

  • Piven, J., Gayle, J., Chase, G. A., Fink, B., Landa, R., Wzorek, M. M., & Folstein, S. E. (1990). A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 177–183.

    Google Scholar 

  • Piven, J., Palmer, P., Jacobi, D., Childress, D., & Arndt, S. (1997). Broader autism phenotype: Evidence from a family history study of multiple-incidence autism families. American Journal of Psychiatry, 154, 185–190.

    Google Scholar 

  • Piven, J., Simon, J., Chase, G. A., Wzorek, M., Landa, R., Gayle, J., & Folstein, S. (1993). The etiology of autism: Pre-, peri-, and neonatal factors. Journal of the American Academy of ChiLd and Adolescent Psychiatry, 32, 1256–1263.

    Google Scholar 

  • Platt, L. D., Koch, R., Azen, C., Hanley, W. B., Levy, H. L., Matalon, R., Rouse, B., de la Cruz, F., & Walla, C. (1992). Maternal phenylketonuria collaborative study, obstetric aspects and outcome. The first 6 years. American Journal of Obstetrics and Gynecology, 166, 1150–1162.

    Google Scholar 

  • Plumet, M.-H., Goldbrum, M.-C., & Leboyer, M. (1995). Verbal skills in relatives of autistic females. Cortex, 31, 723–733.

    Google Scholar 

  • Povey, A., Burley, M. W., Attwood, J., Benham, F., Hunt, D., Jeremiah, S. J., Franklin, S., Gillett, G., Malas, S., Robson, E. B., Tippett, P., Edwards, J. H., Kwiatkowski, D. J., Super, M., Mueller, R., Fryer, A., Clarke, A., Webb, D., & Osborne, J. (1994). Two loci for tuberous sclerosis: One on 9q34 and one on 16p13. Annals of Human Genetics, 58, 107–127.

    Google Scholar 

  • Prechtl, H. (1967). Neurological findings in newborn infants after pre-and perinatal complications. In J. Jonxis, H. Vesses, & J. Troelstra (Eds.), Aspects of prematurity and dysmaturity (pp. 305–321). Springfield, IL: Stenfert Kroese.

    Google Scholar 

  • Risch, N. (1990). Genetic linkage and complex diseases, with special reference to psychiatric disorders. Genetic Epidemiology, 7, 3–7.

    Google Scholar 

  • Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of affected twins. American Journal of Psychiatry, 142, 74–77.

    Google Scholar 

  • Ritvo, E. R., Jorde, L. B., Mason-Brothers, A., Freeman, B. J., Pingree, C., Jones, M. B., McMahon, W. M., Petersen, P. B., Jenson, W. R., & Mo, A. (1989). The UCLA-University of Utah epidemiologic survey of autism: Recurrence risk estimates and genetic counselling. American Journal of Psychiatry, 146, 1032–1036.

    Google Scholar 

  • Robinson, P. D. (1996). Biology. Genetics of autism: The maternal genotype at the dopamine beta hydroxylase locus may be a factor in the etiology of autism and related pervasive developmental disorders. Hamilton, Ontario. McMaster University Department of Biology.

    Google Scholar 

  • Rodrigue, J. R., Geffken, G. R., & Morgan, S. B. (1993). Perceived competence and behavioral adjustment of siblings of children with autism. Journal of Autism and Developmental Disorders, 23, 665–674.

    Google Scholar 

  • Rutter, M. (1994). Debate and argument: There are connections between brain and mind and it is important that Rett syndrome be classified somewhere. Journal of Child Psychology and Psychiatry, 35, 377–378.

    Google Scholar 

  • Rutter, M., Bailey, A., Bolton, P., & Le Couteur, A. (1994). Autism and known medical conditions: Myth and substance. Journal of Child Psychology and Psychiatry, 35, 311–322.

    Google Scholar 

  • Smalley, S. L., & Collins, F. (1996). Brief report: Genetic, prenatal, and immunologic factors. Journal of Autism and Developmental Disorders, 26, 195–198.

    Google Scholar 

  • Smalley, S. L., McCracken, J., & Tanguay, P. (1995). Autism, affective disorders and social phobia. American Journal of Medical Genetics, 60, 19–26.

    Google Scholar 

  • Spiker, D., Lotspeich, L., Kraemer, H. C., Hallmayer, J., McMahon, W., Petersen, P. B., Nicholas, P., Pingree, C., Wiese-Slater, S., Chiotti, C., Wong, D. L., Dimicelli, S., Ritvo, E., Cavalli-Sforza, L. L., & Ciaranello, R. D. (1994). Genetics of autism: Characteristics of affected and unaffected children from 37 multiplex families. American Journal of Medical Genetics, 54, 27–35.

    Google Scholar 

  • Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I., Jakobsson, G., & Bohmai, M. (1989). A twin study of autism in Denmark, Finland, Iceland, Norway, and Sweden. Journal of Child Psychology and Psychiatry, 30, 405–416.

    Google Scholar 

  • Stevenson, R. E., & Huntley, C. C. (1967). Congenital malformations in offspring of phenylketonuric mothers. Pediatrics, 40, 33–45.

    Google Scholar 

  • Stromland, K., Norden, V., Muller, M., Akerstrom, B., & Gillberg, C. (1994). Autism in thalidomide embryopathy: A population study. Developmental Medicine and Child Neurology, 36, 351–356.

    Google Scholar 

  • Szatmari, P. (1992). The validity of autistic spectrum disorders: A literature review. Journal of Autism and Developmental Disorders, 22, 583–600.

    Google Scholar 

  • Szatmari, P., Jones, M. B., Fisman, S., Tuff, L., Bartolucci, G., Mahoney, W. J., & Bryson, S. E. (1995). Parents and collateral relatives of children with Pervasive Developmental Disorders: A family history study. American Journal of Medical Genetics, 60, 282–289.

    Google Scholar 

  • Szatmari, P., Jones, M. B., Holden, J., Bryson, S., Mahoney, W., Tuff, L., MacLean, J., White, B., Bartolucci, G., Schutz, C., Robinson, P., & Hoult, L. (1996). High phenotypic correlations among siblings with autism and pervasive developmental disorders. American Journal of Medical Genetics, 67, 354–360.

    Google Scholar 

  • Szatmari, P., Jones, M. B., MacLean, J. E., Tuff, L., Bartolucci, G., Mahoney, G., Bryson S. E., & Zwaigenbaum, L. (1997). Screening for social-communication impairments in collateral relatives of children with Pervasive Developmental Disorders. In preparation.

  • Szatmari, P., Jones, M. B., Tuff, L., Bartolucci, G., Fisman, S., & Mahoney, W. (1993). Lack of cognitive impairment in first-degree relatives of children with Pervasive Developmental Disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 1264–1273.

    Google Scholar 

  • Thomas, S. A., Matsumoto, A. M., & Palmiter, R. D. (1995). Noradrenaline is essential for mouse fetal development. Nature, 374, 643–646.

    Google Scholar 

  • Todd, R. D. (1992). Neural development is regulated by classical neurotransmitters: Dopamine D2 receptor stimulation enhances neurite outgrowth. Biological Psychiatry, 31, 794–807.

    Google Scholar 

  • Torrey, E. F., Hersh, S. P., & McCabe, K. D. (1975). Early childhood psychosis and bleeding during pregnancy, a prospective study of gravid women and their offspring. Journal of Autism and Childhood Schizophrenia, 5, 287–297.

    Google Scholar 

  • Tsai, L. Y. (1992). Is Rett syndrome a subtype of pervasive developmental disorder? Journal of Autism and Developmental Disorders, 22, 551–561.

    Google Scholar 

  • Tsai, L. Y., & Stewart, M. A. (1983). Etiological implication of maternal age and birth order in infantile autism. Journal of Autism and Developmental Disorders, 13, 57–65.

    Google Scholar 

  • Tsai, L., Stewart, M. A., & August, G. (1981). Implications of sex differences in the familial transmission of infantile autism. Journal of Autism and Developmental Disorders, 11, 165–173.

    Google Scholar 

  • Volkmar, F. R. (1992). Childhood disintegrative disorder: Issues for DSM-IV. Journal of Autism and Developmental Disorders, 22, 625–642.

    Google Scholar 

  • Volkmar, F. R., Klin, A., Siegel, B., Szatmari, P., Lord, C., Campbee, M., Freeman, B. J., Cicchetti, D. V., Rutter, M., Kline, W., Buitelaar, J., Hattab, Y., Fombonne, E., Fuentes, J., Werrt, J., Stone, W., Kerbeshian, J., Hashino, Y., Bregman, J., Loveland, K., Szymanski, L., & Towbin, K. (1994). Field trial for autistic disorder in DSM-IV. American Journal of Psychiatry, 151, 1361–1367.

    Google Scholar 

  • Volkmar, F. R., Szatmari, P., & Sparrow, S. S. (1993). Sex differences in pervasive developmental disorders. Journal of Autism and Developmental Disorders, 23, 579–591.

    Google Scholar 

  • Wahlberg, K. E., Whynne, L. C., Oja, H., Kaskitalo, P., Pykalainen, L., Lahti, I., Moring, J., Naarala, M., Sorri, A., Seitamaa, M., Laksy, X., Kolassa, J., & Tenari, P. (1997). Gene-environment interaction in vulnerability to schizophrenia. American Journal of Psychiatry, 154, 355–362.

    Google Scholar 

  • Weissman, M., Merikangas, K. R., John, J., Wickramaratne, P., Prusoff, B. A., & Kidd, K. K. (1986). Family-genetic studies of psychiatric disorder. Archives of General Psychiatry, 43, 1104–1116.

    Google Scholar 

  • World Health Organization. (1992). InternationaL classification of diseases, 10th ed. Draft of Chapter 5: Categories F00-F99, mental, behavioral developmental disorders. Geneva: Author.

    Google Scholar 

  • Wolf, L. C., Noh, S., Fisman, S. N., & Speechley, M. (1989). Brief report: Psychological effects of parenting stress on parents of autistic children. Journal of Autism and Developmental Disorders, 19, 157–166.

    Google Scholar 

  • Wolff, S., Narayan, S., & Moyes, B. (1988). Personality characteristics of parents of autistic children: A controlled study. Journal of Child Psychology and Psychiatry 29, 143–153.

    Google Scholar 

  • Zwaigenbaum, L., Szatmari, P., MacLean, J. E., Bryson, S. E., Mahoney, W., Bartolucci, G., Tuff, L., & Tsafnat, T. (1997). Obstetric optimality in children with PDD and their siblings: Factors that mediate differences. Manuscript in preparation.

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  1. McMaster University Medical Centre, Hamilton, Ontario, Canada

    P. Szatmari, L. Zwaigenbaum & J. E. MacLean

  2. Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey, Pennsylvania

    M. B. Jones

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Szatmari, P., Jones, M.B., Zwaigenbaum, L. et al. Genetics of Autism: Overview and New Directions. J Autism Dev Disord 28, 351–368 (1998). https://doi.org/10.1023/A:1026096203946

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