Abstract
Leptospirosis is the most widespread zoonosis in the world. It is mostly an occupational disease especially in rural areas. Kolenchery is in the midlands of Kerala. The landscape consists of marshy land and dry land interspersed by rivulets and ponds. Irrigation of dry lands for cultivation during the summer months started in mid 1980s after the irrigation projects were commissioned. Cases of leptospirosis were rarely diagnosed in Kolenchery before 1987. Since then a yearly increase in incidence is observed. No major study on either epidemiology or clinical picture has been done on human leptospirosis in Kerala so far. The aim of this study was to define the major clinical presentations, epidemiology of the infection and demonstrate the predominant serogroups and serovars causing the illness in this limited geographical area. The study involves 976 cases of leptospirosis confirmed by culture and/or serological tests. Serogroups Autumnalis, Australis and Icterohaemorrhagiae were the commonest. Mortality rate was 5.32%. The increase in incidence is probably due to the geographical characteristics, continuous moisture of the soil due to irrigation in summer and year-round cultivation making food and cover available to host rodents. Close interaction of humans, animals, soil and water in this region make the spread of leptospirosis to humans easy. Confirmation of cases has been done by enzyme linked immunosorbent assay (ELISA) and/or microscopic agglutination test (MAT) and/or by culture. Serovar identification has been done in 21 cultures isolated from patients. One new serovar belonging to serogroup Australis has been identified from a patient and named serovar Australis bharathy.
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References
Dikken H, Kmety E, De Geus A, Adinarayanan N, Timmer VEA. Two new leptospira serovars belonging to the hebdomadis serogroup. Trop Geograph Med 1978; 30: 537–542.
Dikken H, Adinarayanan N, Timmer VEA. A new leptospiral servoar from India in the Javancia serogroup. Trop Geograph Med 1981; 33: 339–341.
Muthusethupathy MA, Shivakumar S. Acute renal failure due to leptospirosis. JAPI 1987; 35: 631–633.
Ratnam S. Leptospiral isolates of India in a manual of Leptospirosis. Madras: S.R. Publications, 1994: 159–160.
Ratnam S, Venugopal K, Kathiravan V. Evidence of leptospirosis in human samples in Madras City. Ind J Med 1987: 516–518.
Faine S. Guidelines for the control of Leptospirosis, Offaset Publication No. 67, Geneva: World Health Organisation, 1982.
Chen Ting-Zuo. Development and present status of Leptospiral vaccine and technology of production of vaccine in China. Ann Immun Hung 1986; 26: 125–151.
Lin J. The type of leptospirosis epidemic and serogroup transformation in Fujian Province in recent years. Chung-Hua-Liu-Hsing-Ping-Hsueh-Tsa-Chih 1993 Feb; 14(1): 37–38.
Brenno Babudieri. Control of Leptospirosis. Roma Consiglio Nazionale Delle Ricerche, 1963.
Cacciapuoti B, Ciceroni L, Pinto A, Apollini M, Rondinella V, Bonomi U, Benedetti E, Cinco M, Dessi S, Dettori G, et al. Survey on the prevalence of leptospira infections in the Italian population. Eur J Epidemiol 1994 Apr; 10(2): 173–180.
Biegel E, Mortensen H, Gaub J. Leptospirosis in the Ribe County 1980–1991. Ugeskr-Laeger 1995 Jan 9; 157(2): 157–161.
Kuriakose M, Eapen CK, Punnoose E, Koshi G. Leptospirosis — Clinical spectrum and correlation with 7 simple laboratory tests of early diagnosis in the Third World. Trans of Royal Society of Tropical Medicine and Hygiene 1990; 84: 419–421.
Terpstra WJ. ELISA for the detection of specific IgM and IgG in Human Leptospirosis. Journal of General Microbiology 1985; 131: 377–385.
Terpstra WJ, Lighthart GS, Schoone GJ. Serodiagnosis in Human Leptospirosis by Enzyme Linked Immunosorbent Assay (ELISA) — Department of Tropical Hygiene, Royal Tropical Institute, Amsterdam 1985: 400–405.
Sanford JP. Leptospirosis. In: Braunwald E, Isselbacker KJ, Peters RG, Wilson JD, Fanci AS, Kasper DL, Martin JB (eds), Harrison's Principles of Internal Medicine, 13th edn. New York: McGraw-Hill, 1994: 740–743.
Edwards CN, Hassell TA, Nicholson GD, Everard COR, Callender J. Leptospirosis in Barbados. West Indies Medical Journal 1990; 39: 27–33.
Watt G, Padre LP, and Tarson L. Placebo controlled trails of intravenous penicillin for severe and late leptospirosis. Lancet I 1988: 433–435.
Gonsalves AJ, de Carvalho Je, Guedes de Silva JB, Rozembaum R, Vieira AR. Haemoptysis and the adult respiratory distress syndrome as the causes of death in leptopsirosis: Changes in the clinical and anatomico-pathological patterns. Rev Soc Bras Med Trop 25(4) 1992; 261–270.
Kuriakose M, Eapen CK, John MM, Paul R. A pilot study of the prevalence of leptospiral infection in the local population around Kolenchery. Kerala Med J 1994; 58–62.
Daiter AB, Shibalov VA, Stoinova NA, Sleptsova VI, Semenovich VN. Leptospira Infection under the natural conditions of the environs of Saint Petersburg. Zh-Mikrobiol-Epidemiol-Immunobiol 1993; Jan–Feb(1): 28–33.
Kovovin IL, Chernukha YP. Serological classification of leptospirae of Grippotyphosa Serogroup: A new serotype ratnapura. J Microbiol (Moscow) 1970; 10: 102–105.
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Kuriakose, M., Eapen, C. & Paul, R. Leptospirosis in Kolenchery, Kerala, India: Epidemiology, prevalent local serogroups and servoars and a new serovar. Eur J Epidemiol 13, 691–697 (1997). https://doi.org/10.1023/A:1007300729615
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DOI: https://doi.org/10.1023/A:1007300729615