Original ArticleComparison of Biomarkers and Parent Report of Tobacco Exposure to Predict Wheeze
Section snippets
Methods
We used data from the Health Outcomes and Measures of the Environment (HOME) Study. The HOME Study is a prospective birth cohort study designed to investigate the effects of prenatal and postnatal exposure to environmental toxicants on the development and behaviors of children. The HOME Study enrolled 468 English-speaking women at 16 (± 2 weeks) gestation who were ≥18 years of age and lived in a home built before 1979. Women were observed through pregnancy, and their children are still being
Results
Participants for whom data were available were more likely to be white, have a mother with more than a high school education, have private insurance, live in non-urban environment, have married parents, have an older mother, have a higher income, have reportedly less prenatal tobacco exposure, and have a lower maternal mean prenatal cotinine level (Table I).
Twelve percent of mothers reported active exposure, and 26% of mothers reported active or passive exposure (Table I). Cotinine was
Discussion
Only 26% of mothers in this cohort reported active or passive tobacco exposure, but >60% of mothers had measurable levels of exposure with serum cotinine. Thus, many pregnant women may not recognize or may underreport tobacco exposure. This exposure can have important health effects for the mother and the fetus. We found that higher levels of prenatal tobacco exposure were associated with increased odds of wheeze in children during the first 2 years after birth; however, the magnitude of this
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Active smoking, environmental tobacco smoke and bronchitic symptoms among adolescents in Taiwan: A prospective cohort study
2014, Preventive MedicineCitation Excerpt :The measurement of active smoking and ETS exposure by questionnaire may be relatively imprecise. However, the validity of exposure estimates based on questionnaire responses has been found to provide reasonably valid data and Spanier et al. (2011) observed that the parental reporting of ETS may underestimate the risk of respiratory diseases in children. Another limitation to this study is the potential misclassification of respiratory diseases that may lead to underestimation of the effect estimates.
Prenatal tobacco exposure, biomarkers for tobacco in meconium, and neonatal growth outcomes
2013, Journal of PediatricsCitation Excerpt :However, marker concentrations for tobacco in meconium did not predict severity of neonatal effects. Sherif et al23 showed a negative correlation between birth weight and cotinine concentrations in meconium; however, our data and others2,14,25 more recently showed relationships only with positivity of meconium or categorically high (95th percentile) concentrations and poor infant outcomes. More research is needed on timing of maternal quitting of tobacco smoking and effects on infant outcomes.
Supported by Flight Attendant Medical Research Foundation Young Clinical Scientist Award and the National Institute of Environmental Health Sciences (1K23ES016304 and PO1ES11261). The authors declare no conflicts of interest.