Original ArticleHigh Flow Nasal Cannulae Therapy in Infants with Bronchiolitis
Section snippets
Methods
The Fisher Paykel heated HFNC system (MR850 humidification system; Fisher & Paykel Healthcare) became available at our institution in September 2006. Low-resistance nasal cannulae available included the infant cannulae with a maximum flow rate of 7 L/min and the pediatric cannulae with a maximum flow rate of 8 L/min. Most of the infants in this study were admitted to the PICU from the emergency department or were transferred to the PICU from the general pediatrics unit. HFNC oxygen therapy was
Results
One hundred fifteen infants met all of the inclusion and none of the exclusion criteria and were included in the analysis, 57 from before the introduction of HFNC (2005–2006, HFNC-NA group) and 58 from the season after the introduction of HFNC (2006–2007, HFNC-A group). The age, weight, gestational age, sex, RSV status, and Pediatric Index of Mortality 216 score were similar between the two groups (Table I). More children in the HFNC-NA group had a history of prematurity, defined as a
Discussion
In this retrospective chart review, infants < 24 months of age who presented to the PICU with bronchiolitis demonstrated a 68% decrease in need for intubation with the introduction of HFNC therapy. This difference is unlikely to be explained by other patient characteristics, because the groups were similar at baseline. In addition, the difference persisted in a logistic regression controlling for age, weight, RSV status, and gestational age. External factors other than the introduction of HFNC
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The authors declare no conflicts of interest.