The Journal of Allergy and Clinical Immunology: In Practice
Original ArticleRisk of Asthma in Late Preterm Infants: A Propensity Score Approach
Section snippets
Methods
This study protocol was approved by Institutional Review Boards at Mayo Clinic and Olmsted Medical Center.
Characteristics of subjects
During the period 1976 to 1982, a total of 7463 children were born to mothers who were residents of the city of Rochester at the time of their delivery. Twenty-one children died at birth, yielding 7442 children in the birth cohort for follow-up. An additional 402 infants born less than 34 weeks of gestation were excluded. This left 7040 children in our study (median follow-up of 3.8 person-years). Of these 7040 children who met the study eligibility, 333 were born LPT (4%) (6707 children were
Discussion
In our population-based birth cohort study using the PSA to reduce covariate imbalance, we found that there was no significant difference in risk of asthma between LPT and term infants. The PSA might be a useful tool for research concerning asthma epidemiology where random assignment of exposure is not feasible.
We believe that the finding of no association between LPT and risk of asthma in our study is not due to lack of statistical power. For example, the literature showed that the effect size
Acknowledgments
We thank the Pediatric Asthma Epidemiology Research Unit's staff for their comments and suggestions. Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases (R21 AI101277) and the Scholarly Clinician Award from the Mayo Foundation. It was also made possible by the support from the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676.
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Cited by (0)
This work was supported by the Clinician Scholarly Award from the Mayo Foundation and it was made possible by the Rochester Epidemiology Project (R01-AG34676) from the National Institute on Aging.
Conflicts of interest: The authors declare that they have no relevant conflicts.