The Journal of Allergy and Clinical Immunology: In Practice
Original articleThe Utility of Peanut Components in the Diagnosis of IgE-Mediated Peanut Allergy Among Distinct Populations
Section snippets
Patient selection
The study was approved by local institutional review board for the following 4 sites: Mount Sinai, Consortium of Food Allergy Research (CoFAR), Sachs Open, and Sachs Double-blind.
At the Mount Sinai site, patients referred for a double-blind oral food challenge (OFC) to peanut from a university-based outpatient pediatric allergy clinic (Mount Sinai, New York, NY) were invited to participate. They were eligible for entry if they had a clinical history for peanut allergy and evidence of peanut
Baseline characteristics
In total, 167 patients had serum analyzed for peanut components and completed an OFC to peanut. The median age of all patients was 11.7 years [interquartile range (IQR), 7.0-15.0 years]. The patients in the CoFAR group were older than the other patients (P < .005) and those in the Mount Sinai cohort were younger than the other patients (P < .005). Most were male (n = 108; 64.7%), and this breakdown was similar in all groups (Table II).
OFC results
Breakdown of results of peanut challenges are presented in
Discussion
We present data from peanut component analysis drawn before oral peanut challenge in patients with suspected peanut allergy from various cohorts in 2 different nations. This work is similar to some prior studies on peanut component testing. However, it is the first to examine peanut component analysis with the use of standardized methods from multiple cohorts of patients with suspected peanut allergy, all of whom underwent oral peanut challenges, which was not the case in many previous studies.
Acknowledgments
We thank all the parents and children who participated in this study. We also thank all members of the Consortium of Food Allergy Research (CoFAR), including the study nurses, data managers, and the principal investigators at each site (Drs Scott Sicherer, Robert Wood, David Fleischer, Stacie Jones, and Wesley Burks). Support for CoFAR was made possible through grants from the National Institute of Allergy and Infectious Diseases (NIAID) (U19AI066738 and U01AI066560).
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No funding was received for this work.
Conflicts of interest: S. Glaumann has received research support from the Mjolkdroppen Foundation, Swedish Asthma and Allergy Association's Research Foundation, Centre for Allergy Research at Karolinska Institutet, Hesselman Foundation, Foundation Samariten, and Princess Lovisa's Association for Children's Medical Care. H. A. Sampson is on the Danone Scientific Advisory Board, has received consultancy fees from Allertein Therapeutics and the Food Allergy Initiative, is employed by Mount Sinai Medical School, has received research and travel support from the National Institute of Allergy and Infectious Diseases/National Institutes of Health, receives royalties from Elsevier-Wiley and UpToDate, and is 42.5% share owner in Hers Springs, LLC. C. Nilsson has received research support from the Centre for Allergy Research at Karolinska Institutet, Asthma and Allergy Association, Hesselman Foundation, Mjolkdroppen Foundation, and The Crownprincess Lovisa research foundation. The rest of the authors declare that they have no relevant conflicts.
Cite this article as: Lieberman JA, Glaumann S, Batelsson S, Borres MP, Sampson HA, Nilsson C. The utility of peanut components in the diagnosis of IgE-mediated peanut allergy among distinct populations. J Allergy Clin Immunol: In Practice 2013;1:75-82. http://dx.doi.org/10.1016/j.jaip.2012.11.002.
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Current affiliation for J. A. Lieberman is the Division of Allergy & Immunology, Department of Pediatrics, The University of Tennessee, Memphis, Tenn.