Asthma and lower airway diseaseEarly-term birth is a risk factor for wheezing in childhood: A cross-sectional population study
Section snippets
Respiratory and Neurological Outcomes of Children born Preterm Study
We conducted a cross-sectional population-based study of children in Wales to explore the association between gestational age at birth and the risk of respiratory illness, hospital admissions, and other health-related outcomes in the first 10 years of life. In brief, we invited 13,361 preterm-born children and 13,361 term-born matched control subjects in 2013, with birth dates from January 1, 2003, to December 31, 2011, to complete a survey on respiratory and neurological health-based outcomes.
Characteristics of responders
From 13,361 term-born children invited to take part, 2,845 (21.3%) were included in the analyses after exclusion of 6 respondents. Responders had similar characteristics to nonresponders except for higher WIMD scores (Table I, Table II and see Tables E1 and E2 in this article's Online Repository at www.jacionline.org). Comparing early term–born children (both age groups) with full term–born control subjects did not show a statistically significant difference for sex, age, WIMD score, ethnicity,
Discussion
The aim of this cross-sectional study was to collect data on respiratory-related outcomes for children who were born early or full term. Our results show that early term–born children up to 10 years of age had up to 70% greater risk of respiratory symptoms and up to 50% greater inhaler use than similarly aged term-born children. Early term–born children aged 5 years or greater also had increased risk of chest infections and antibiotic use when compared with those born at full term. The risk of
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Supported in part by Mason Medical Research Foundation and CYPRN.
Disclosure of potential conflict of interest: M. O. Edwards has received research support from the Mason Medical Research Foundation and the Children and Young People's Research Network (CYPRN Wales) and has received travel support from CYPRN Wales. S. Kotecha has consultant arrangements with VoluSense Norway and has received research support from the Medical Research Council, the European Union Framework Programme 7, and the Welsh government. The rest of the authors declare that they have no relevant conflicts of interest.