Original articlePediatric cardiacChanges of Brain Magnetic Resonance Imaging Findings After Congenital Aortic Arch Anomaly Repair Using Regional Cerebral Perfusion in Neonates and Young Infants
Section snippets
Patients and Methods
From May 2008 to August 2009, 11 neonates (9 younger than 30 days) and young infants (n = 2, aged 38 days and 40 days) who underwent surgical repair of congenital aortic arch anomalies and their concomitant intracardiac anomalies were enrolled in this prospective study. The University Ethics Committee reviewed and approved this study (approval number H-0803-043-238), and fully informed written consent regarding the preoperative and postoperative neurologic study and evaluation, the
Patient Profile and Surgical Outcomes
The median age of the patients at the time of operation was 11 days (range: 5 to 46 days), the median body weight was 3.72 kg (range: 2.43 to 4.4 kg), and the body surface area was 0.23 m2 (range: 0.17 to 0.26 m2). The number of male patients was 10. The diagnoses included CoA with ventricular septal defect, atrial septal defect or atrioventricular septal defect (n = 7), CoA with supramitral ring (n = 1), CoA with Taussig-Bing anomaly (n = 1), interrupted aortic arch with ventricular septal
Comment
There are various causes of unexpected adverse neurologic outcomes after cardiac surgery in neonates and young infants. There are nonmodifiable factors such as genetic syndromes, but there are also modifiable factors such as perioperative hypoxic or ischemic insults, and intraoperative situations, including deep hypothermic total circulatory arrest [5]. The advances in CPB techniques, the myocardial protection protocols, and the surgical techniques and instruments have overcome these modifiable
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