ResearchObstetricsGestational weight gain and child adiposity at age 3 years
Section snippets
Population and study design
Study subjects were participants in Project Viva, a prospective cohort study of pregnant women and their children. We previously reported the recruitment protocols.8 Mothers provided informed consent. The human subjects committee of Harvard Pilgrim Health Care approved all study protocols.
Of 2128 women who delivered a live singleton infant, 1585 women enrolled for continuation beyond 6 months after delivery. At the time of this analysis, 1110 children had completed the study visit at age 3
Results
Mean (SD) maternal prepregnancy BMI was 24.6 kg/m2 (5.0), and total gestational weight gain was 15.6 kg (5.4). Approximately one-third (29%) of mothers had a prepregnancy BMI > 26.0 kg/m2. According to the 1990 Institute of Medicine recommendations, 51% of women gained excessive weight, 35% gained adequate weight, and 14% gained inadequate weight (Table 1). Mean (SD) child BMI z-score was 0.45 units (1.01), and 9% of children were overweight (BMI ≥ 95th percentile for age and sex).
On bivariate
Comment
In this prospective study of over 1000 mother-child pairs, we found that mothers with greater gestational weight gain had children with more adiposity at 3 years of age, measured by skinfold thickness as well as by BMI. This association was independent of parental BMI, maternal glucose tolerance, breastfeeding duration, fetal and infant growth, and child behaviors. Children of mothers who gained more weight also had somewhat higher systolic blood pressure, a cardiovascular risk factor related
References (36)
- et al.
A critique of the new recommendations for weight gain in pregnancy
Am J Obstet Gynecol
(1996) - et al.
Role of the prenatal environment in the development of obesity
J Pediatr
(1998) - et al.
Trends in fetal growth among singleton gestations in the United States and Canada, 1985 through 1998
Semin Perinatol
(2002) - et al.
Why are babies getting bigger? Temporal trends in fetal growth and its determinants
J Pediatr
(2002) - et al.
Pre-pregnancy and pregnancy-related factors and the risk of excessive or inadequate gestational weight gain
Int J Gynaecol Obstet
(2005) - et al.
Maternal obesity and breast-feeding practices
Am J Clin Nutr
(2003) - (1990)
- Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Munson ML. Births: final data for 2003. Natl Vital Stat Rep...
- et al.
Trends in pregnancy weight gain within and outside ranges recommended by the Institute of Medicine in a WIC population
Matern Child Health J
(1998) - et al.
Point of diminishing returns: When does gestational weight gain cease benefiting birthweight and begin adding to maternal obesity?
J Matern Fetal Med
(1996)
Fetal origins of obesity
Obes Res
Associations of maternal prenatal smoking with child adiposity and blood pressure
Obes Res
Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships
Diabetes
Early life risk factors for obesity in childhood: cohort study
BMJ
Predicting obesity in young adulthood from childhood and parental obesity
N Engl J Med
Obesity and leanness at birth and their relationship to body habitus in later childhood
Pediatrics
Parental and perinatal factors associated with childhood obesity in north-east Italy
Int J Obes Relat Metab Disord
Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy
Pediatrics
Cited by (0)
Supported by grants from the US National Institutes of Health (HD 34568, HL 64925, HL 68041, HD 44807), the Robert Wood Johnson Foundation, Harvard Medical School, and the Harvard Pilgrim Health Care Foundation.
Preliminary findings were presented at the International Congress of the Society for Developmental Origins of Health and Disease, Toronto, Canada, November 15-16, 2005.
Cite this article as: Oken E, Taveras EM, Kleinman KP, Rich-Edwards JW, Gillman MW. Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol 2007;196:322.e1-322.e8.