Reduced GABA synthesis in pyridoxine-dependent seizures
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Cited by (67)
Vitamin B<inf>6</inf>
2023, Encyclopedia of Human Nutrition: Volume 1-4, Fourth EditionL-lactic acidosis: pathophysiology, classification, and causes; emphasis on biochemical and metabolic basis
2020, Kidney InternationalCitation Excerpt :Pyridoxine is a cofactor for the reaction catalyzed by the enzyme glutamic acid decarboxylase, in which glutamate is converted to γ-amino butyric acid. Because γ-amino butyric acid activates inhibitory receptors, a deficiency of this acid could result in increased neuronal excitability, leading to the development of seizures.86 Pyridoxine deficiency may occur in patients taking the drug isoniazid, commonly used to treat tuberculosis, because of the formation of an isoniazid/vitamin B6 complex.87
Role of pyridoxine in GABA synthesis and degradation in the hippocampus
2019, Tissue and CellCitation Excerpt :Administration of 180 mg/kg pyridoxine improves the anxiolytic-like behavior in mice and increases GABA levels (Walia et al., 2017) and decreases the glutamate and nitrite levels compared to that of the control group (Walia et al., 2017). However, the deficiency of pyridoxine decreases GABA levels or GAD activity in the cortex (Gospe et al., 1994; Gospe, 2002; Baxter, 2003; Mills et al., 2006). In Escherichia coli, pyridoxine supplementation significantly increases GAD production (Plokhov et al., 2000).
Lithium potentiated, pyridoxine abolished and fluoxetine attenuated the anxiolytic effect of diazepam in mice
2019, Brain Research BulletinCitation Excerpt :Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter, synthesized by enzyme glutamate decarboxylase (GAD) which utilizes pyridoxal-5′-phosphate (PLP) as a cofactor in the synthesis of GABA (Pearl et al., 2006; Kästner et al., 2007). Thus the impaired expression of GAD and the reduced availability of PLP affect the level of GABA which is further characterized by several neurological and behavioral manifestations (Gospe et al., 1994). It has already been reported that GABA is involved in the pathogenesis of anxiety and the infusion of GABA agonists in amygdala evoke anxiolytic effect while the infusion of GABA antagonists evoke anxiogenic effect (Palomares-Castillo et al., 2012; Barbalho et al., 2009).
Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth
2018, International Journal of Developmental Neuroscience