Elsevier

The Lancet

Volume 309, Issue 8017, 23 April 1977, Pages 894-897
The Lancet

Occasional Surveys
FATAL DEXTROPROPOXYPHENE POISONING IN NORTHERN IRELAND: Review of 30 Cases

https://doi.org/10.1016/S0140-6736(77)91212-0Get rights and content

Abstract

Data from 30 fatal cases of dextropropoxyphene poisoning occurring in Northern Ireland over three years have been studied. All the victims had ingested more than therapeutic amounts, and many had also taken alcohol or other drugs. Most of the deaths were probably suicides. Death occurred very rapidly suggesting that the narcotic effects of dextropropoxyphene predominated, and this may explain the scarcity of clinical reports. It is suggested that many doctors are unaware of the danger of dextropropoxyphene in overdosage and that the problem of dextropropoxyphene poisoning in the United Kingdom has not been fully appreciated. This supposition, if correct, highlights the absence of a satisfactory early-warning system for serious drug effects including death.

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