Group B streptococcal disease in UK and Irish infants younger than 90 days

Summary

The incidence, morbidity, and mortality of group B streptococcal disease in the UK and Republic of Ireland are largely unknown. Between Feb 1, 2000, and Feb 28, 2001, we identified cases of invasive group B streptococcal disease in infants younger than 90 days through surveillance involving paediatricians, microbiologists, and parents. 568 cases were identified, equivalent to a total incidence of 0·72 per 1000 live-births (95% CI 0·66–0·78); the incidence for early-onset disease (n=377) was 0·48 per 1000 (0·43–0·53), and for late-onset disease (n=191) was 0·24 per 1000 (0·21–0·28). Risk factors were identifiable for 218 (58%) cases of early-onset disease. 53 infants died (overall 9·7%). We have established the minimum current burden of group B streptococcal disease in UK and Irish infants. This information will assist in the formulation of guidelines for prevention of this disease.