Gastrointestinal hemorrhage complicating aspirin therapy in acute Kawasaki disease
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Medium- or Higher-Dose Acetylsalicylic Acid for Acute Kawasaki Disease and Patient Outcomes
2017, Journal of PediatricsCitation Excerpt :These results suggest that the use of medium- or higher-dose ASA is not protective against CAA, at the very least. Although complications related to high-dose ASA, including anemia,12 gastrointestinal hemorrhage,18 and Reye syndrome,19-21 have been reported previously, high- or medium-dose ASA has been used as standard therapy for preventing coronary artery lesions in patients with acute Kawasaki disease. The efficacy of high-dose ASA in reducing coronary involvement in Kawasaki disease was reported in 1 study.22
Kawasaki Disease
2012, Pediatric Clinics of North AmericaCitation Excerpt :High-dose ASA, unlike lower doses of ASA, can decrease prostacyclin, which has an important role in interfering with thrombus formation.85,88 As well, high-dose ASA can have potential toxicity, including Reye syndrome,89 raised liver enzymes,85 gastrointestinal bleeding,90 and sensorineural hearing loss.46 Although high-dose ASA has been shown to shorten the duration of fever compared with moderate-dose85 or low-dose ASA,91 it is unclear if it has any effect on CAA.
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