Multiple organ involvement in perinatal asphyxia☆,☆☆,★
Section snippets
Patients
The study population comprised asphyxiated term neonates admitted consecutively to the neonatal unit at La Paz Children's Hospital, Autonoma University of Madrid, between January 1990 and February 1992. The infants were identified as having had perinatal asphyxia when at least three of the following criteria were present: (1) fetal scalp blood pH <7.20, (2) umbilical cord arterial pH <7.20, (3) Apgar scores <4 at 1 minute and/or <7 at 5 minutes, (4) requirement of more than 1 minute of positive
RESULTS
Seventy-two asphyxiated term infants were studied. During the study period, 85 consecutive patients met the entry criteria. Thirteen of these infants were excluded: seven because of congenital malformations, two because of maternal heroin addiction, and four because parental consent was not given. Seventy infants were born at our institution; two infants born elsewhere were admitted on the first day of life.
DISCUSSION
These results indicate that perinatal asphyxia, defined by the presence of at least three traditional criteria, is frequently followed by dysfunction of one or more organs during the neonatal period. Involvement of at least one organ was found in 82% of the infants (95% confidence interval, 72% to 91%) and severe involvement of one or more organs in 28% (95% confidence interval, 17% to 39%). In addition, our findings indicate that the Apgar score at 5 minutes in infants with other putative
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From the Department of Pediatrics, Division of Neonatology and Division of Pediatric Cardiology, La Paz Children's Hospital, Autonoma University of Madrid, Madrid, Spain
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Reprint requests: A. Martín-Ancel, MD, Division of Neonatology, La Paz Children's Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.
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0022-3476/95/$5.00 + 0 9/23/67467