Effects of DNA methylation on DNA-binding proteins and gene expression

doi:10.1016/0959-437X(93)90027-M

Current Opinion in Genetics & Development

Volume 3, Issue 2, 1993, Pages 226-231

https://doi.org/10.1016/0959-437X(93)90027-M Get rights and content

Abstract

DNA methyltransferase is needed for normal development, perhaps because DNA methylation plays a part in the control of gene activity. It is clear that the methylation of promoters often leads to repression of transcription. Studies of the mechanism suggest that repression may either result from the direct effects of methylation on transcription factors, or may be indirectly caused by repressor proteins that bind to methylated DNA.

Current evidence suggests that both mechanisms can be involved.

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Effects of DNA methylation on DNA-binding proteins and gene expression

Abstract

Cell

Nature

Cell

Biochem J

Cell

Nucleic Acids Res

EMBO J

Gene

J Immunol

Developmental Pattern of Gene-specific DNA Methylation in the Mouse Embryo and Germ Line

Genes Dev

Temporal and Regional Changes in DNA Methylation in the Embryonic, Extraembryonic and Germ Cell Lineages during Mouse Embryo Development

Development

In Vivo Footprint and Methylation Analysis by PCR-aided Genomic Sequencing: Comparison of Active and Inactive X Chro mosomal DNA at the CpG Island and Promoter of Human PGK-1

Genes Dev

Methylation of the Hypoxanthine Phosphoribosyltmnsferase Locus on the Human X Chromosome: Implications for X chromosome Inactivation

X-chromosome Inactivation and Cell Memory

Trends Genet

Parental Legacy Determines Methylation and Expression of an Autosomal Transgene: A Molecular Mechanism for Parental Imprinting

Cell

Parental Imprinting: Potentially Active Chromatin of the Repressed Maternal Allele of the Mouse Insulin-like Growth Factor II Igf2 ) Gene

Genes Dev

Methylation of an Alpha-foetoprotein Gene Intragenic Site Modulates Gene Activity

Nucleic Acids Res

Methylation of Discrete Sites Within the Enhancer Region Regulates the Activity of the Epstein-Barr Virus BamHI W Promoter in Burkitt Lymphoma Lines

J Virol

Gene Silencing in Mammalian Cells by Direct Incorporation of Electroporated 5-Methyl-2′-Deoxycytidine 5′-Triphosphate

Somat Cell Mol Genet

Gene Silencing in Mammalian Cells by Uptake of 5-Methyl Deoxycytidine-5′-Triphosphate

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Polymerase Chain Reaction-aided Genomic Sequencing of an X Chromosome-linked CpG Island: Methylation Pat terns Suggest Clonal Inheritance, CpG Site Autonomy, and an Explanation of Activity State Stability

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A Genomic Sequencing Protocol that Yields a Positive Display of 5-methylcytosine Residues in Individual DNA Strands

Cloning, Characterisation, and Expression in Escherichia coli of the Gene Coding for the CpG DNA Methylase from Spiroplasma sp. Strain MQ1 M.Sssl)

Nucleic Acids Res

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EMBO J

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Biocbem Biophys Res Comm